دورية أكاديمية
أعرض في EDS

Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats.

التفاصيل البيبلوغرافية
العنوان: Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats.
المؤلفون: Prince MRU; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh., Zihad SMNK; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.; University of Chinese Academy of Sciences, Beijing, China., Ghosh P; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh., Sifat N; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh., Rouf R; Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Vietnam.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Al Shajib GM; Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna, Bangladesh., Alam MA; Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh., Shilpi JA; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh., Uddin SJ; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.
المصدر: Frontiers in nutrition [Front Nutr] 2021 May 10; Vol. 8, pp. 653918. Date of Electronic Publication: 2021 May 10 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]-
مستخلص: Amaranthus spinosus is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples of A. spinosus significantly reduced weight gain, organ weight, and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with A. spinosus powder, methanol extract, and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized by the test samples. A. spinosus boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet-fed obese rats which was brought down by A. spinosus . Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity-induced metabolic disorders, making it a prospective food supplement.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Prince, Zihad, Ghosh, Sifat, Rouf, Al Shajib, Alam, Shilpi and Uddin.)
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فهرسة مساهمة: Keywords: Amaranthus spinosus; antioxidant; glucose intolerance; obesity; steatosis
تواريخ الأحداث: Date Created: 20210527 Latest Revision: 20231111
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8142894
DOI: 10.3389/fnut.2021.653918
PMID: 34041259
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-861X
DOI:10.3389/fnut.2021.653918