دورية أكاديمية
Investigation of endophenotype potential of decreased fractional anisotropy in pediatric bipolar disorder patients and unrelated offspring of bipolar disorder patients.
| العنوان: | Investigation of endophenotype potential of decreased fractional anisotropy in pediatric bipolar disorder patients and unrelated offspring of bipolar disorder patients. |
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| المؤلفون: | Camkurt MA; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Melicher T; Department of Psychiatry, UNI Downtown Clinic, University of Utah Medical School, Salt Lake City, Utah, USA.; National Institute of Mental Health, Klecany, Czech Republic., Mwangi B; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Wu MJ; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Cao B; Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada., Zeni CP; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Tannous J; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Zunta-Soares G; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Hasan K; Department of Radiology, John P. and Katherine G. McGovern Medical School at UT Health, Houston, Texas, USA., Sanches M; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Soares JC; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA. |
| المصدر: | CNS spectrums [CNS Spectr] 2022 Dec; Vol. 27 (6), pp. 709-715. Date of Electronic Publication: 2021 May 28. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: United States NLM ID: 9702877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-8529 (Print) Linking ISSN: 10928529 NLM ISO Abbreviation: CNS Spectr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Nov. 2011- : New York : Cambridge University Press Original Publication: New York, NY : MBL Communications, c1996- |
| مواضيع طبية MeSH: | Bipolar Disorder*/diagnosis, Adult ; Adolescent ; Humans ; Child ; Anisotropy ; Endophenotypes ; Diffusion Tensor Imaging/methods ; Prospective Studies ; Reproducibility of Results |
| مستخلص: | Background: Bipolar disorder (BD) is a severe psychiatric disorder associated with structural and functional brain abnormalities, some of which have been found in unaffected relatives as well. In this study, we examined the potential role of decreased fractional anisotropy (FA) as a BD endophenotype, in adolescents at high risk for BD. Methods: We included 15 offspring of patients with BD, 16 pediatric BD patients, and 16 matched controls. Diffusion weighted scans were obtained on a 3T scanner using an echo-planar sequence. Scans were segmented using FreeSurfer. Results: Our results showed significantly decreased FA in six brain areas of offspring group; left superior temporal gyrus (LSTG; P < .0001), left transverse temporal gyrus (LTTG; P = .002), left banks of the superior temporal sulcus (LBSTS; P = .002), left anterior cingulum (LAC; P = .003), right temporal pole (RTP; P = .004) and left frontal pole (LFP; P = .017). On analysis, LSTG, LAC, and RTP demonstrated a potential to be an endophenotype when comparing all three groups. FA values in three regions, LBSTS, LTTG, and LFP were increased only in controls. Conclusion: Our findings point at decreased FA as a possible endophenotype for BD, as they were found in children of patients with BD. Most of these areas were previously found to have morphological and functional changes in adult and pediatric BD, and are thought to play important roles in affected domains of functioning. Prospective follow up studies should be performed to detect reliability of decreased FA as an endophenotype and effects of treatment on FA. |
| فهرسة مساهمة: | Keywords: Diffusion tensor imaging; biomarker; bipolar disorder; endophenotype; fractional anisotropy |
| تواريخ الأحداث: | Date Created: 20210528 Date Completed: 20221206 Latest Revision: 20230127 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1017/S1092852921000584 |
| PMID: | 34044907 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1092-8529 |
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| DOI: | 10.1017/S1092852921000584 |