دورية أكاديمية
Effects of danofloxacin dosing regimen on gastrointestinal pharmacokinetics and fecal microbiome in steers.
| العنوان: | Effects of danofloxacin dosing regimen on gastrointestinal pharmacokinetics and fecal microbiome in steers. |
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| المؤلفون: | Halleran JL; Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, NC, USA. jlhaller@ncsu.edu., Callahan BJ; Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, NC, USA., Jacob ME; Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, NC, USA., Sylvester HJ; Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, NC, USA., Prange T; Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC, USA., Papich MG; Deparment of Biomedical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC, USA., Foster DM; Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, NC, USA. |
| المصدر: | Scientific reports [Sci Rep] 2021 May 27; Vol. 11 (1), pp. 11249. Date of Electronic Publication: 2021 May 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Enterococcus/*drug effects , Escherichia coli/*drug effects , Fluoroquinolones/*pharmacology , Gastrointestinal Microbiome/*drug effects , Gastrointestinal Tract/*microbiology, Animals ; Cattle ; Gastrointestinal Tract/drug effects ; Male |
| مستخلص: | Fluoroquinolones are a class of antimicrobial commonly used in human medicine, and deemed critical by the World Health Organization. Nonetheless, two formulations are approved for the treatment of respiratory disease in beef cattle. The objective of this study was to determine the gastrointestinal pharmacokinetics and impact on enteric bacteria of cattle when receiving one of the two dosing regimens (high: 40 mg/kg SC once or low: 20 mg/kg IM q48hr) of danofloxacin, a commonly utilized synthetic fluoroquinolone in veterinary medicine. Danofloxacin was administered to 12 steers (age 7 months) fitted with intestinal ultrafiltration devices at two different dosing regimens to assess the gastrointestinal pharmacokinetics, the shifts in the gastrointestinal microbiome and the development of resistant bacterial isolates. Our results demonstrated high intestinal penetration of danofloxacin for both dosing groups, as well as, significant differences in MIC values for E. coli and Enterococcus between dosing groups at selected time points over a 38 day period. Danofloxacin treatment consistently resulted in the Euryarchaeota phyla decreasing over time, specifically due to a decrease in Methanobrevibacter. Although microbiome differences were minor between dosing groups, the low dose group had a higher number of isolates with MIC values high enough to cause clinically relevant resistance. This information would help guide veterinarians as to appropriate dosing schemes to minimize the spread of antimicrobial resistance. |
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| معلومات مُعتمدة: | R35 GM133745 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Fluoroquinolones) 24CU1YS91D (danofloxacin) |
| تواريخ الأحداث: | Date Created: 20210528 Date Completed: 20211108 Latest Revision: 20211108 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8160337 |
| DOI: | 10.1038/s41598-021-90647-z |
| PMID: | 34045586 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-021-90647-z |