دورية أكاديمية
Effects of Age on White Matter Microstructure in Children With Neurofibromatosis Type 1.
| العنوان: | Effects of Age on White Matter Microstructure in Children With Neurofibromatosis Type 1. |
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| المؤلفون: | Tam LT; Neurology, 10623Stanford Hospital and Clinics, Palo Alto, CA, USA., Ng NN; Neurology, 10623Stanford Hospital and Clinics, Palo Alto, CA, USA., McKenna ES; Neurology, 10623Stanford Hospital and Clinics, Palo Alto, CA, USA., Bruckert L; Neonatal and Developmental Medicine, 10624Stanford University School of Medicine, Stanford, CA, USA., Yeom KW; Radiology, 10623Stanford Hospital and Clinics, Stanford, CA, USA.; Co-senior authors., Campen CJ; Neurology, 10623Stanford Hospital and Clinics, Palo Alto, CA, USA.; Co-senior authors. |
| المصدر: | Journal of child neurology [J Child Neurol] 2021 Sep; Vol. 36 (10), pp. 894-900. Date of Electronic Publication: 2021 May 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 8606714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-8283 (Electronic) Linking ISSN: 08830738 NLM ISO Abbreviation: J Child Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Thousand Oaks, CA : Sage Original Publication: Littleton, MA : PSG Pub. Co., c1986- |
| مواضيع طبية MeSH: | Diffusion Tensor Imaging/*methods , Neurofibromatosis 1/*diagnostic imaging , White Matter/*diagnostic imaging, Adolescent ; Age Factors ; Anisotropy ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Infant ; Male ; Retrospective Studies |
| مستخلص: | Children with neurofibromatosis type 1 (NF1) often report cognitive challenges, though the etiology of such remains an area of active investigation. With the advent of treatments that may affect white matter microstructure, understanding the effects of age on white matter aberrancies in NF1 becomes crucial in determining the timing of such therapeutic interventions. A cross-sectional study was performed with diffusion tensor imaging from 18 NF1 children and 26 age-matched controls. Fractional anisotropy was determined by region of interest analyses for both groups over the corpus callosum, cingulate, and bilateral frontal and temporal white matter regions. Two-way analyses of variance were done with both ages combined and age-stratified into early childhood, middle childhood, and adolescence. Significant differences in fractional anisotropy between NF1 and controls were seen in the corpus callosum and frontal white matter regions when ages were combined. When stratified by age, we found that this difference was largely driven by the early childhood (1-5.9 years) and middle childhood (6-11.9 years) age groups, whereas no significant differences were appreciable in the adolescence age group (12-18 years). This study demonstrates age-related effects on white matter microstructure disorganization in NF1, suggesting that the appropriate timing of therapeutic intervention may be in early childhood. |
| فهرسة مساهمة: | Keywords: DTI; age; neurofibromatosis; neuroradiology; white matter microstructure |
| تواريخ الأحداث: | Date Created: 20210528 Date Completed: 20220225 Latest Revision: 20220225 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/08830738211008736 |
| PMID: | 34048307 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1708-8283 |
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| DOI: | 10.1177/08830738211008736 |