دورية أكاديمية
أعرض في EDS

Chemical composition and potentiating action of Norfloxacin mediated by the essential oil of Piper caldense C.D.C. against Staphylococcus aureus strains overexpressing efflux pump genes.

التفاصيل البيبلوغرافية
العنوان: Chemical composition and potentiating action of Norfloxacin mediated by the essential oil of Piper caldense C.D.C. against Staphylococcus aureus strains overexpressing efflux pump genes.
المؤلفون: Leal ALAB; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.; Department of Microbiology and Parasitolog, Federal University of Piaui, Teresina, PI, Brazil., Bezerra CF; Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil., Confortin C; Postgraduate Programme in Sustainable Territorial, Federal University of Paraná, Curitiba, PR, Brazil., da Silva LE; Postgraduate Programme in Sustainable Territorial, Federal University of Paraná, Curitiba, PR, Brazil., Marinho EM; Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Fortaleza, CE, Brazil., Marinho MM; Faculty of Education, Science and Letters of Iguatu, State University of Ceará, Iguatu, CE, Brazil., Vasconcelos MA; Minas Gerais State University, Divinópolis Unit, MG, Brazil., da Silva TG; Department of Antibiotics, Drug Planning and Synthesis Laboratory-LPSF, Federal University of Pernambuco, Cidade Universitária, Recife, PE, Brazil., Marinho ES; Group of Theoretical Chemistry and Electrochemistry, State University of Ceará, Campus FAFIDAM, Limoeiro do Norte, Fortaleza, CE, Brazil., Teixeira AMR; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Coutinho HDM; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Barreto HM; Department of Microbiology and Parasitolog, Federal University of Piaui, Teresina, PI, Brazil., Dos Santos HS; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil. helciodossantos@gmail.com.; Center for Exact Sciences and Technology, Vale do Acarau State University, Sobral, CE, Brazil. helciodossantos@gmail.com.
المصدر: Archives of microbiology [Arch Microbiol] 2021 Sep; Vol. 203 (7), pp. 4727-4736. Date of Electronic Publication: 2021 May 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Methicillin-Resistant Staphylococcus aureus* , Norfloxacin*/chemistry , Norfloxacin*/pharmacology , Oils, Volatile*/pharmacology , Piper*/chemistry , Piper*/metabolism , Staphylococcus aureus*/drug effects , Staphylococcus aureus*/genetics, Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Multidrug Resistance-Associated Proteins
مستخلص: Infectious diseases caused by multidrug-resistant microorganisms has increased in the last years. Piper species have been reported as a natural source of phytochemicals that can help in combating fungal and bacterial infections. This study had as objectives characterize the chemical composition of the essential oil from Piper caldense (EOPC), evaluate its potential antimicrobial activity, and investigate the synergistic effect with Norfloxacin against multidrug-resistant S. aureus overproducing efflux pumps, as well as, verify the EOPC ability to inhibit the Candida albicans filamentation. EOPC was extracted by hydrodistillation, and the chemical constituents were identified by gas chromatography, allowing the identification of 24 compounds (91.9%) classified as hydrocarbon sesquiterpenes (49.6%) and oxygenated sesquiterpenes (39.5%). Antimicrobial tests were performed using a 96-well plate microdilution method against C. albicans ATCC 10231, Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 standard strains, as well as against multidrug-resistant strains S. aureus SA1199B (overexpressing norA gene), S. aureus K2068 (overexpressing mepA gene) and S. aureus K4100 (overexpressing qacC gene). The oil showed activity against C. albicans ATCC 10231 (≥ 512 µg/mL) and was able to inhibit hyphae formation, an important mechanism of virulence of C. albicans. On the other hand, EOPC was inactive against all bacterial strains tested (≤ 1,024 µg mL). However, when combined with Norfloxacin at subinhibitory concentration EOPC reduced the Norfloxacin and Ethidium bromide MIC values against S. aureus strains SA1199B, K2068 and K4100. These results indicate that EOPC is a source of phytochemicals acting as NorA, MepA and QacC inhibitors.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
References: J Ethnopharmacol. 2007 Apr 4;110(3):391-400. (PMID: 17317057)
Antimicrob Agents Chemother. 1993 Jan;37(1):128-9. (PMID: 8431010)
F1000Res. 2016 Oct 26;5:2582. (PMID: 27853524)
Antibiotics (Basel). 2020 Jun 20;9(6):. (PMID: 32575738)
Med Chem. 2015;11(2):135-55. (PMID: 25181985)
Trends Mol Med. 2007 Jun;13(6):260-7. (PMID: 17493872)
Phytochemistry. 2003 Oct;64(3):743-52. (PMID: 13679097)
Saudi J Biol Sci. 2018 Jan;25(1):37-43. (PMID: 29379354)
Antimicrob Agents Chemother. 2005 May;49(5):1857-64. (PMID: 15855507)
PLoS Pathog. 2006 Jul;2(7):e63. (PMID: 16839200)
Braz J Anesthesiol. 2018 Jan - Feb;68(1):69-74. (PMID: 28870386)
Fungal Genet Biol. 2011 Aug;48(8):747-63. (PMID: 21513811)
Food Chem Toxicol. 2019 Sep;131:110559. (PMID: 31176927)
Mycopathologia. 1999 Nov;148(2):79-82. (PMID: 11189747)
Rev Soc Bras Med Trop. 2011 Nov-Dec;44(6):740-4. (PMID: 22094708)
Nat Prod Commun. 2010 Sep;5(9):1365-8. (PMID: 20922992)
Front Microbiol. 2020 Apr 29;11:801. (PMID: 32411120)
Molecules. 2016 Jun 08;21(6):. (PMID: 27338314)
J Cell Biol. 2004 Feb 16;164(4):581-91. (PMID: 14769857)
Braz J Microbiol. 2013 Mar 19;44(1):29-35. (PMID: 24159280)
EMBO J. 1997 Apr 15;16(8):1982-91. (PMID: 9155024)
BMC Complement Altern Med. 2017 Jan 31;17(1):82. (PMID: 28143473)
Nat Microbiol. 2016 Sep 27;1(10):16187. (PMID: 27670123)
J Pharm Anal. 2016 Apr;6(2):71-79. (PMID: 29403965)
Bioorg Med Chem Lett. 2021 Jan 1;31:127670. (PMID: 33161124)
J Hosp Infect. 2020 Mar;104(3):246-251. (PMID: 32035997)
Gene. 1991 May 15;101(1):59-66. (PMID: 1840534)
Eur J Pharm Sci. 2013 Jan 23;48(1-2):80-6. (PMID: 23111348)
Sci Rep. 2020 Sep 24;10(1):15647. (PMID: 32973295)
Curr Drug Metab. 2021;22(2):114-122. (PMID: 32445452)
Curr Opin Microbiol. 2001 Apr;4(2):214-21. (PMID: 11282479)
Antimicrob Agents Chemother. 1999 Oct;43(10):2404-8. (PMID: 10508015)
Microb Pathog. 2018 Nov;124:5-10. (PMID: 30092261)
Comp Immunol Microbiol Infect Dis. 2010 Dec;33(6):467-71. (PMID: 19732954)
BMC Infect Dis. 2015 Feb 03;15:40. (PMID: 25645440)
Antimicrob Agents Chemother. 1993 May;37(5):1086-94. (PMID: 8517696)
Med Mycol. 2009 May;47(3):268-75. (PMID: 19347739)
Nat Rev Microbiol. 2018 Sep;16(9):523-539. (PMID: 30002505)
Antimicrob Agents Chemother. 2015 Jan;59(1):747-8. (PMID: 25403665)
Planta Med. 2001 Nov;67(8):771-3. (PMID: 11731928)
Sci Rep. 2020 Aug 6;10(1):13243. (PMID: 32764618)
J Tradit Complement Med. 2020 Feb 28;11(2):130-136. (PMID: 33728273)
Microb Pathog. 2017 Jun;107:280-286. (PMID: 28385578)
J Appl Microbiol. 2016 Nov;121(5):1312-1322. (PMID: 27537678)
Indian J Med Res. 2013 Jan;137(1):178-82. (PMID: 23481069)
فهرسة مساهمة: Keywords: Antibacterial; Antifungal; Efflux pump inhibitors; Essential oil; Fungal dimorphism; Piper caldense
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Bacterial Proteins)
0 (Multidrug Resistance-Associated Proteins)
0 (Oils, Volatile)
N0F8P22L1P (Norfloxacin)
تواريخ الأحداث: Date Created: 20210530 Date Completed: 20210901 Latest Revision: 20230207
رمز التحديث: 20230207
مُعرف محوري في PubMed: PMC8164493
DOI: 10.1007/s00203-021-02393-5
PMID: 34052872
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-072X
DOI:10.1007/s00203-021-02393-5