دورية أكاديمية
أعرض في EDS

Anti-inflammatory role of curcumin in retinal disorders (Review).

التفاصيل البيبلوغرافية
العنوان: Anti-inflammatory role of curcumin in retinal disorders (Review).
المؤلفون: Franzone F; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Nebbioso M; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Pergolizzi T; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Attanasio G; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Musacchio A; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Greco A; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Limoli PG; Low Vision Research Centre of Milan, I-20145 Milan, Italy., Artico M; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy., Spandidos DA; Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Greece., Taurone S; IRCCS-Fondazione Bietti, I-00198 Rome, Italy., Agostinelli E; Department of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, I-00161 Rome, Italy.; International Polyamines Foundation ETS-ONLUS, I-00159 Rome, Italy.
المصدر: Experimental and therapeutic medicine [Exp Ther Med] 2021 Jul; Vol. 22 (1), pp. 790. Date of Electronic Publication: 2021 May 21.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Spandidos Pub.] Country of Publication: Greece NLM ID: 101531947 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1792-0981 (Print) Linking ISSN: 17920981 NLM ISO Abbreviation: Exp Ther Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Athens : Spandidos Pub.]
مستخلص: Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione], the main component of turmeric ( Curcuma longa , a flowering plant of the ginger family, Zingiberaceae), is known to possess different pharmacological activities, particularly anti-inflammatory and antioxidant properties. Since an underlying inflammatory process exists in several ocular conditions, such as anterior uveitis, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR), the aim of the present review was to summarize the pleiotropic effects exerted by this molecule, focusing in particular on its beneficial role in retinal diseases. The anti-inflammatory activity of curcumin has also been described in numerous systemic inflammatory pathologies and tumors. Specifically, the biological, pharmaceutical and nutraceutical properties of curcumin are associated with its ability to downregulate the expression of the following genes: IκBα, cyclooxygenase 2, prostaglandin E2, interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor-α. According to this finding, curcumin may be useful in the treatment of some retinal disorders. In DR, proliferative vitreoretinopathy and AMD, beneficial effects have been observed following treatment with curcumin, including slowing down of the inflammatory process. Despite the aforementioned evidence, the main disadvantage of this substance is that it possesses a low solubility, as well as poor oral bioavailability due to its reduced absorption, rapid metabolism and rapid elimination. Therefore, several curcumin analogues have been synthesized and tested over the years, in order to improve the possible obtainable therapeutic effects. The purpose of the present review was to identify new aspects that could guide future research on this important traditional medicine, which is a well-tolerated natural product, and is widely considered safe and economical.
Competing Interests: DAS is the Editor-in-Chief for the journal, but had no personal involvement in the reviewing process, or any influence in terms of adjudicating on the final decision, for this article. The other authors declare that they have no competing interests.
(Copyright: © Franzone et al.)
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فهرسة مساهمة: Keywords: DR; ROS; curcumin; epidermal growth factor; polymeric micelles; protein kinases
تواريخ الأحداث: Date Created: 20210531 Latest Revision: 20210601
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8145690
DOI: 10.3892/etm.2021.10222
PMID: 34055089
قاعدة البيانات: MEDLINE
الوصف
تدمد:1792-0981
DOI:10.3892/etm.2021.10222