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Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP.

التفاصيل البيبلوغرافية
العنوان: Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP.
المؤلفون: Steel RWJ; Seattle Children's Research Institute, Seattle, WA, USA.; Infectious Diseases and Immune Defence Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Vigdorovich V; Seattle Children's Research Institute, Seattle, WA, USA., Dambrauskas N; Seattle Children's Research Institute, Seattle, WA, USA., Wilder BK; Seattle Children's Research Institute, Seattle, WA, USA.; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, 97006, USA., Arredondo SA; Seattle Children's Research Institute, Seattle, WA, USA., Goswami D; Seattle Children's Research Institute, Seattle, WA, USA., Kumar S; Seattle Children's Research Institute, Seattle, WA, USA., Carbonetti S; Seattle Children's Research Institute, Seattle, WA, USA., Swearingen KE; Institute for Systems Biology, Seattle, WA, USA., Nguyen T; Seattle Children's Research Institute, Seattle, WA, USA., Betz W; Seattle Children's Research Institute, Seattle, WA, USA., Camargo N; Seattle Children's Research Institute, Seattle, WA, USA., Fisher BS; Seattle Children's Research Institute, Seattle, WA, USA., Soden J; Retrogenix Ltd, Chinley, High Peak, SK23 6FJ, UK., Thomas H; Retrogenix Ltd, Chinley, High Peak, SK23 6FJ, UK., Freeth J; Retrogenix Ltd, Chinley, High Peak, SK23 6FJ, UK., Moritz RL; Institute for Systems Biology, Seattle, WA, USA., Noah Sather D; Seattle Children's Research Institute, Seattle, WA, USA. noah.sather@seattlechildrens.org.; Department of Pediatrics, University of Washington, Seattle, WA, USA. noah.sather@seattlechildrens.org.; Department of Global Health, University of Washington, Seattle, WA, USA. noah.sather@seattlechildrens.org., Kappe SHI; Seattle Children's Research Institute, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.; Department of Pediatrics, University of Washington, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.; Department of Global Health, University of Washington, Seattle, WA, USA. stefan.kappe@seattlechildrens.org.
المصدر: Scientific reports [Sci Rep] 2021 May 31; Vol. 11 (1), pp. 11328. Date of Electronic Publication: 2021 May 31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Host-Pathogen Interactions*, Plasmodium falciparum/*metabolism , Protozoan Proteins/*metabolism , Receptor, Platelet-Derived Growth Factor beta/*metabolism, HEK293 Cells ; Humans ; Plasmodium vivax/metabolism ; Plasmodium yoelii/metabolism ; Protozoan Proteins/isolation & purification
مستخلص: Following their inoculation by the bite of an infected Anopheles mosquito, the malaria parasite sporozoite forms travel from the bite site in the skin into the bloodstream, which transports them to the liver. The thrombospondin-related anonymous protein (TRAP) is a type 1 transmembrane protein that is released from secretory organelles and relocalized on the sporozoite plasma membrane. TRAP is required for sporozoite motility and host infection, and its extracellular portion contains adhesive domains that are predicted to engage host receptors. Here, we identified the human platelet-derived growth factor receptor β (hPDGFRβ) as one such protein receptor. Deletion constructs showed that the von Willebrand factor type A and thrombospondin repeat domains of TRAP are both required for optimal binding to hPDGFRβ-expressing cells. We also demonstrate that this interaction is conserved in the human-infective parasite Plasmodium vivax, but not the rodent-infective parasite Plasmodium yoelii. We observed expression of hPDGFRβ mainly in cells associated with the vasculature suggesting that TRAP:hPDGFRβ interaction may play a role in the recognition of blood vessels by invading sporozoites.
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معلومات مُعتمدة: R01 AI134956 United States AI NIAID NIH HHS; R01 GM087221 United States GM NIGMS NIH HHS; K25AI119229 United States NH NIH HHS; R01GM087221 United States NH NIH HHS
المشرفين على المادة: 0 (Protozoan Proteins)
120300-02-9 (thrombospondin-related adhesive protein, protozoan)
EC 2.7.10.1 (PDGFRB protein, human)
EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor beta)
تواريخ الأحداث: Date Created: 20210601 Date Completed: 20211119 Latest Revision: 20240505
رمز التحديث: 20240505
مُعرف محوري في PubMed: PMC8166973
DOI: 10.1038/s41598-021-90722-5
PMID: 34059712
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-90722-5