دورية أكاديمية
Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea.
العنوان: | Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea. |
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المؤلفون: | Hamida ME; Department of Microbiology, Orotta College of Medicine and Health Sciences, PO Box: 1034, Asmara, Eritrea. mohelfatih77@gmail.com., Raja SM; Department of Internal Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea., Petros Y; Unit of Molecular Biology, National Animal and Plant Health Laboratory, Asmara, Eritrea., Wahab M; Unit of Molecular Biology, National Animal and Plant Health Laboratory, Asmara, Eritrea., Seyoum Y; Department of Internal Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea., Elkhidir IM; Department of Microbiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Tekle F; National Health Laboratory, Department of Serology, Ministry of Health, Asmara, Eritrea. |
المصدر: | Scientific reports [Sci Rep] 2021 May 31; Vol. 11 (1), pp. 11323. Date of Electronic Publication: 2021 May 31. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Hepatitis B/*virology , Hepatitis B virus/*genetics, Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Eritrea/epidemiology ; Female ; Genotype ; Hepatitis B/epidemiology ; Humans ; Male ; Middle Aged ; Viral Load ; Young Adult |
مستخلص: | Eritrea is an East African multiethnic country with an intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of hepatitis B virus (HBV) among patients with liver disease. A total of 293 Eritrean patients with liver disease who were hepatitis B surface antigen (HBsAg) positive were enrolled. All sera were tested for liver transaminases, HBV DNA viral load, and hepatitis B seromarkers including HBsAg, anti-HBcAb (total), HBeAg, and anti-HBeAb. Those reactive for HBsAg and anti-HBc (total) were further tested for HBV genotyping. The median (interquartile range) of HBV DNA viral load and ALT levels were 3.47 (1.66) log IU/mL and 28 (15.3) IU/L, respectively. Using type-specific primer-based genotyping method, 122/293 (41.6%) could be genotyped. Irrespective of mode of occurrence, HBV genotype D (21.3%) was the predominant circulating genotype, followed by genotypes C (17.2%), E (15.6%), C/D (13.1%), and C/E (10.7%). Genotypes C/D/E (7.4%), A/D (4.9%), D/E (4.1%), A (2.5%), and B, A/E, B/E, and A/D/C (0.8%) were also present. HBV in Eritrea is comprised of a mixture of HBV genotypes. This is the first study of HBV genotyping among patients with liver disease in Eritrea. |
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تواريخ الأحداث: | Date Created: 20210601 Date Completed: 20211119 Latest Revision: 20211119 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8166852 |
DOI: | 10.1038/s41598-021-90836-w |
PMID: | 34059763 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-021-90836-w |