دورية أكاديمية
Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea.
| العنوان: | Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea. |
|---|---|
| المؤلفون: | Hamida ME; Department of Microbiology, Orotta College of Medicine and Health Sciences, PO Box: 1034, Asmara, Eritrea. mohelfatih77@gmail.com., Raja SM; Department of Internal Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea., Petros Y; Unit of Molecular Biology, National Animal and Plant Health Laboratory, Asmara, Eritrea., Wahab M; Unit of Molecular Biology, National Animal and Plant Health Laboratory, Asmara, Eritrea., Seyoum Y; Department of Internal Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea., Elkhidir IM; Department of Microbiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Tekle F; National Health Laboratory, Department of Serology, Ministry of Health, Asmara, Eritrea. |
| المصدر: | Scientific reports [Sci Rep] 2021 May 31; Vol. 11 (1), pp. 11323. Date of Electronic Publication: 2021 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Hepatitis B/*virology , Hepatitis B virus/*genetics, Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Eritrea/epidemiology ; Female ; Genotype ; Hepatitis B/epidemiology ; Humans ; Male ; Middle Aged ; Viral Load ; Young Adult |
| مستخلص: | Eritrea is an East African multiethnic country with an intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of hepatitis B virus (HBV) among patients with liver disease. A total of 293 Eritrean patients with liver disease who were hepatitis B surface antigen (HBsAg) positive were enrolled. All sera were tested for liver transaminases, HBV DNA viral load, and hepatitis B seromarkers including HBsAg, anti-HBcAb (total), HBeAg, and anti-HBeAb. Those reactive for HBsAg and anti-HBc (total) were further tested for HBV genotyping. The median (interquartile range) of HBV DNA viral load and ALT levels were 3.47 (1.66) log IU/mL and 28 (15.3) IU/L, respectively. Using type-specific primer-based genotyping method, 122/293 (41.6%) could be genotyped. Irrespective of mode of occurrence, HBV genotype D (21.3%) was the predominant circulating genotype, followed by genotypes C (17.2%), E (15.6%), C/D (13.1%), and C/E (10.7%). Genotypes C/D/E (7.4%), A/D (4.9%), D/E (4.1%), A (2.5%), and B, A/E, B/E, and A/D/C (0.8%) were also present. HBV in Eritrea is comprised of a mixture of HBV genotypes. This is the first study of HBV genotyping among patients with liver disease in Eritrea. |
| References: | Braz J Infect Dis. 2018 Jul - Aug;22(4):294-304. (PMID: 30092176) World J Gastroenterol. 2007 Aug 21;13(31):4260-3. (PMID: 17696258) World J Gastroenterol. 2015 Nov 14;21(42):11941-53. (PMID: 26576083) Int J Infect Dis. 2014 Dec;29:125-32. (PMID: 25449246) PLoS One. 2010 Feb 19;5(2):e9297. (PMID: 20174575) Int J Infect Dis. 2010 Nov;14(11):e941-53. (PMID: 20674432) J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:123-30. (PMID: 21199523) Rev Med Virol. 2016 Jul;26(4):285-303. (PMID: 27139263) BMC Infect Dis. 2013 Jul 18;13:328. (PMID: 23865777) Niger Postgrad Med J. 2019 Apr-Jun;26(2):80-86. (PMID: 31187746) Lancet. 2016 Sep 10;388(10049):1081-1088. (PMID: 27394647) J Viral Hepat. 2005 Mar;12(2):192-8. (PMID: 15720535) J Med Virol. 2003 Aug;70(4):529-36. (PMID: 12794714) Vaccine. 2005 Mar 31;23(19):2409-23. (PMID: 15752827) Braz J Infect Dis. 2015 Sep-Oct;19(5):525-8. (PMID: 25997779) J Virol. 2009 Oct;83(20):10538-47. (PMID: 19640977) PLoS One. 2018 Feb 20;13(2):e0193177. (PMID: 29462187) Hepatol Res. 2007 Jul;37(s1):S9-S19. (PMID: 17627641) J Clin Microbiol. 2001 Jan;39(1):362-4. (PMID: 11136801) Intervirology. 2008;51(6):417-21. (PMID: 19258721) Mol Biol Rep. 2011 Oct;38(7):4353-7. (PMID: 21181276) |
| تواريخ الأحداث: | Date Created: 20210601 Date Completed: 20211119 Latest Revision: 20211119 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8166852 |
| DOI: | 10.1038/s41598-021-90836-w |
| PMID: | 34059763 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-021-90836-w |