دورية أكاديمية
أعرض في EDS

Understanding the evolution of multiple drug resistance in structured populations.

التفاصيل البيبلوغرافية
العنوان: Understanding the evolution of multiple drug resistance in structured populations.
المؤلفون: McLeod DV; Centre D'Ecologie Fonctionnelle & Evolutive, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France., Gandon S; Centre D'Ecologie Fonctionnelle & Evolutive, CNRS, Univ Montpellier, EPHE, IRD, Montpellier, France.
المصدر: ELife [Elife] 2021 Jun 01; Vol. 10. Date of Electronic Publication: 2021 Jun 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Biological Evolution* , Linkage Disequilibrium* , Models, Genetic*, Anti-Bacterial Agents/*therapeutic use , Bacteria/*genetics , Bacterial Infections/*drug therapy , Drug Resistance, Multiple, Bacterial/*genetics, Bacteria/drug effects ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Epistasis, Genetic ; Gene-Environment Interaction ; Humans ; Mutation ; Population Dynamics ; Time Factors
مستخلص: The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here, we argue that studying MDR evolution by focusing upon the dynamical equations for linkage disequilibrium (LD) can greatly simplify the calculations, generate more insight, and provide a unified framework for understanding the role of population structure. We demonstrate how a general epidemiological model of MDR evolution can be recast in terms of the LD equations. These equations reveal how the different forces generating and propagating LD operate in a dynamical setting at both the population and metapopulation levels. We then apply these insights to show how the LD perspective: (i) explains equilibrium patterns of MDR, (ii) provides a simple interpretative framework for transient evolutionary dynamics, and (iii) can be used to assess the consequences of different drug prescription strategies for MDR evolution.
Competing Interests: DM, SG No competing interests declared
(© 2021, McLeod and Gandon.)
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فهرسة مساهمة: Keywords: antibiotic resistance; ecology; evolutionary biology; evolutionary epidemiology; linkage disequilibrium; multidrug resistance; none
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20210601 Date Completed: 20211019 Latest Revision: 20211019
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8208818
DOI: 10.7554/eLife.65645
PMID: 34061029
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.65645