دورية أكاديمية
أعرض في EDS

Clinical and Radiological Profiles of COVID-19 Patients with Neurological Symptomatology: A Comparative Study.

التفاصيل البيبلوغرافية
العنوان: Clinical and Radiological Profiles of COVID-19 Patients with Neurological Symptomatology: A Comparative Study.
المؤلفون: Aragao MFVV; Centro de Biociências, Anatomy Department, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.; Centro Diagnostico Multimagem, Recife 50070-450, Brazil., Leal MC; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.; Real Hospital Português de Beneficência em Pernambuco, Recife 50050-290, Brazil., Andrade PHP; Centro de Ciências Médicas, Faculdade de Medicina do Recife, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Cartaxo Filho OQ; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Aragao LV; Endoscopy Department, Hospital 9 de Julho, São Paulo 01409-002, Brazil., Fonseca TM; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Valenca MA; Centro de Ciências Médicas, Faculdade de Medicina do Recife, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Leao MRVC; Centro de Ciências Médicas, Faculdade de Medicina do Recife, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Aragao JPV; Faculdade de Medicina de Olinda, Olinda 53030-030, Brazil., Soares ML; Propedeutics Department, Áreas de Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Alagoas, Alagoas 57072-970, Brazil.; Department of Morphological and Functional Organization 1, 2 and 3, Centro Universitário Cesmac, Alagoas 57051-160, Brazil., Lima MP; Real Hospital Português de Beneficência em Pernambuco, Recife 50050-290, Brazil., Caldas SS; Surgery Department, Post Graduation on Helth Human Communation, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.; Centro de Ciências Médicas, Surgery Department, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Valenca MM; Centro de Ciências Médicas, Pós Graduation Neuropsquiatry Department, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
المصدر: Viruses [Viruses] 2021 May 06; Vol. 13 (5). Date of Electronic Publication: 2021 May 06.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: COVID-19/*diagnostic imaging , Neuroimaging/*methods, Adult ; Aged ; Brain/diagnostic imaging ; Brain/pathology ; Brazil/epidemiology ; COVID-19/metabolism ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Tomography, X-Ray Computed/methods
مستخلص: Patients with COVID-19 can require radiological examination, with chest CT being more frequent than neuro-imaging. The objective is to identify epidemiological, clinical and radiological factors considered as predictors of neurological involvement in patients with COVID-19 assessed by neuroimaging and to describe the neuroimaging findings. This retrospective study was performed with 232 consecutive confirmed COVID-19 patients, from two radiological units, which were divided into two groups: (1) those who underwent a brain CT/MRI scan (n = 35) versus (2) those who did not undergo the brain CT/MRI scan, but underwent only chest CT ( n = 197). There was a statistically significant difference with associations regarding the COVID-19 brain scan group for: admission to ICU, greater severity of lung injuries, the use of a mechanical ventilator and sepsis. Statistical tendency was found for chronic renal failure and systemic arterial hypertension. Forty-percent of COVID-19 patients from the brain scan group were abnormal on brain CT and/or brain MRI (22.9% of the cases with bleeding or microbleeding, 8.6% with restricted diffusion lesions). One ischemic stroke case was associated with irregularity at the M1 segment of the right middle cerebral artery. There was a case of left facial nerve palsy with enhancement of the left geniculate ganglia. An analysis of the olfactory bulbs was possible in 12 brain MRIs and 100% had enhancement and/or microbleeding. In conclusion, a more severe COVID-19 disease from ICU, a more severe form of lung disease, the use of mechanical ventilator and sepsis were associated to the COVID-19 patients with neurological involvement who had undergone brain scans. Microvascular phenomenon was a frequent finding in the brain and olfactory bulbs evaluated by neuroimaging.
References: Head Neck. 2020 Jun;42(6):1252-1258. (PMID: 32342566)
Neurology. 2020 Aug 4;95(5):224-225. (PMID: 32444492)
Stroke Vasc Neurol. 2020 Sep;5(3):279-284. (PMID: 32616524)
AJNR Am J Neuroradiol. 2020 Jul;41(7):1173-1176. (PMID: 32439646)
Braz J Otorhinolaryngol. 2020 Jul - Aug;86(4):490-496. (PMID: 32534982)
N Engl J Med. 2021 Feb 4;384(5):481-483. (PMID: 33378608)
Lancet. 2020 Feb 15;395(10223):497-506. (PMID: 31986264)
AJNR Am J Neuroradiol. 2020 Nov;41(11):2017-2019. (PMID: 32819898)
AJNR Am J Neuroradiol. 2020 Sep;41(9):1703-1706. (PMID: 32586960)
Stroke. 2020 Sep;51(9):2649-2655. (PMID: 32755456)
JAMA Neurol. 2020 Jun 1;77(6):683-690. (PMID: 32275288)
Microbes Infect. 2020 Oct;22(9):481-488. (PMID: 32561409)
AJNR Am J Neuroradiol. 2020 Sep;41(9):1641-1645. (PMID: 32586959)
Clin Infect Dis. 2020 Jul 28;71(15):889-890. (PMID: 32215618)
AJNR Am J Neuroradiol. 2020 Sep;41(9):1707-1711. (PMID: 32586958)
J Med Virol. 2020 Jun;92(6):552-555. (PMID: 32104915)
AJNR Am J Neuroradiol. 2020 Sep;41(9):1625-1628. (PMID: 32732269)
AJNR Am J Neuroradiol. 2021 Jul;42(7):E37-E38. (PMID: 33766826)
Thromb Haemost. 2020 Jun;120(6):998-1000. (PMID: 32316063)
J Infect. 2020 Nov;81(5):816-846. (PMID: 32739489)
Lancet. 2020 May 2;395(10234):1417-1418. (PMID: 32325026)
Eur J Case Rep Intern Med. 2020 Apr 29;7(5):001691. (PMID: 32399457)
Radiology. 2020 Sep;296(3):E184-E185. (PMID: 32407258)
J Neurol Sci. 2020 Jul 15;414:116871. (PMID: 32422428)
Radiology. 2020 Aug;296(2):E119-E120. (PMID: 32228363)
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261. (PMID: 32253535)
Radiology. 2020 Dec;297(3):E324-E334. (PMID: 32729812)
Nature. 2003 Nov 27;426(6965):450-4. (PMID: 14647384)
Radiology. 2020 Nov;297(2):E274-E275. (PMID: 32484418)
AJNR Am J Neuroradiol. 2020 Dec;41(12):2206-2208. (PMID: 32816769)
Biochem Biophys Res Commun. 2020 Jul 30;528(3):413-419. (PMID: 32513532)
Radiology. 2020 Oct;297(1):E223-E227. (PMID: 32437314)
BMJ. 2020 Apr 17;369:m1470. (PMID: 32303495)
Nat Commun. 2020 Oct 30;11(1):5493. (PMID: 33127906)
AJNR Am J Neuroradiol. 2020 Oct;41(10):1905-1907. (PMID: 32819904)
Int Forum Allergy Rhinol. 2020 Jul;10(7):806-813. (PMID: 32279441)
Stroke Vasc Neurol. 2020 Dec;5(4):315-322. (PMID: 33208493)
Acta Neuropathol. 2020 Sep;140(3):397-400. (PMID: 32638079)
AJNR Am J Neuroradiol. 2020 Dec;41(12):2204-2205. (PMID: 32883665)
Radiology. 2020 Nov;297(2):E242-E251. (PMID: 32544034)
فهرسة مساهمة: Keywords: COVID-19; CT; MRI; brain; olfactory bulb; radiology; risk factors; stroke
تواريخ الأحداث: Date Created: 20210602 Date Completed: 20210701 Latest Revision: 20240811
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC8148596
DOI: 10.3390/v13050845
PMID: 34066524
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v13050845