دورية أكاديمية
Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters.
| العنوان: | Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters. |
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| المؤلفون: | Crippa JA; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.; Instituto Nacional de Ciência e Tecnologia, Medicina Translacional (INCT-TM), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Ribeirão Preto, SP, Brazil., Pereira Junior LC; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil., Pereira LC; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil., Zimmermann PM; Prati-Donaduzzi, Toledo, PR, Brazil., Brum Junior L; Prati-Donaduzzi, Toledo, PR, Brazil., Rechia LM; Prati-Donaduzzi, Toledo, PR, Brazil., Dias I; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil., Hallak JE; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.; Instituto Nacional de Ciência e Tecnologia, Medicina Translacional (INCT-TM), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Ribeirão Preto, SP, Brazil., Campos AC; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.; Departamento de Farmacologia, FMRP, USP, Ribeirão Preto, SP, Brazil., Guimarães FS; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.; Departamento de Farmacologia, FMRP, USP, Ribeirão Preto, SP, Brazil., Queiroz RH; Instituto Nacional de Ciência e Tecnologia, Medicina Translacional (INCT-TM), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Ribeirão Preto, SP, Brazil.; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil., Zuardi AW; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.; Instituto Nacional de Ciência e Tecnologia, Medicina Translacional (INCT-TM), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Ribeirão Preto, SP, Brazil. |
| المصدر: | Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2022 Jan-Feb; Vol. 44 (1), pp. 15-20. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Brasileira de Psiquiatria Country of Publication: Brazil NLM ID: 100895975 Publication Model: Print Cited Medium: Internet ISSN: 1809-452X (Electronic) Linking ISSN: 15164446 NLM ISO Abbreviation: Braz J Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo, SP, Brasil : Associação Brasileira de Psiquiatria, [1999]- |
| مواضيع طبية MeSH: | Cannabidiol*/chemistry , Cannabidiol*/pharmacology , Emotions* , Facial Recognition* , Pharmaceutical Vehicles*, Administration, Oral ; Double-Blind Method ; Drug Compounding ; Humans ; Male |
| مستخلص: | Objective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. Methods: In a randomized, double-blind, placebo-controlled, parallel-group design, 45 healthy male volunteers were randomly assigned to three groups of 15 subjects that received either 150 mg of CBD powder; 150 mg of CBD dissolved in corn oil; or placebo. Blood samples were collected at different times after administration, and a facial emotion recognition task was completed after 150 min. Results: There were no significant differences across groups in the subjective and physiological measures, nor in the facial emotion recognition task. However, groups that received the drug showed statistically significant differences in baseline measures of plasma CBD, with a significantly greater difference in favor of the oil formulation. Conclusion: When administered as a single 150-mg dose, neither formulation of oral CBD altered responses to emotional stimuli in healthy subjects. The oil-based CBD formulation resulted in more rapid achievement of peak plasma level, with an approximate fourfold increase in oral bioavailability. |
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| المشرفين على المادة: | 0 (Pharmaceutical Vehicles) 19GBJ60SN5 (Cannabidiol) |
| تواريخ الأحداث: | Date Created: 20210602 Date Completed: 20220217 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8827362 |
| DOI: | 10.1590/1516-4446-2020-1684 |
| PMID: | 34076067 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1809-452X |
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| DOI: | 10.1590/1516-4446-2020-1684 |