دورية أكاديمية
Paternal obesity and its transgenerational effects on gastrointestinal function in male rat offspring.
| العنوان: | Paternal obesity and its transgenerational effects on gastrointestinal function in male rat offspring. |
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| المؤلفون: | Machado MPR; Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil., Gama LA; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil., Beckmann APS; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil., Hauschildt AT; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Dall'Agnol DJR; Faculdade de Ciências Agrárias, Biológicas, Engenharia e da Saúde, Universidade do Estado de Mato Grosso, Tangará da Serra, MT, Brasil., Miranda JRA; Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil., Corá LA; Núcleo de Ciências Biológicas, NUCIB, Universidade Estadual de Ciências da Saúde de Alagoas (UNCISAL), Maceió, AL, Brasil., Américo MF; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, MT, Brasil. |
| المصدر: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2021 May 31; Vol. 54 (9), pp. e11116. Date of Electronic Publication: 2021 May 31 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: eCollection Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981- |
| مواضيع طبية MeSH: | Obesity*/etiology , Paternal Exposure*, Animals ; Female ; Gastrointestinal Motility ; Gastrointestinal Transit ; Insulin ; Leptin ; Male ; Pregnancy ; Rats |
| مستخلص: | The interplay between obesity and gastrointestinal (GI) motility is contradictory, and the transgenerational influence on this parameter is unknown. We aimed to evaluate the GI function in a model of paternal obesity and two subsequent generations of their male offspring. Newborn male rats were treated with monosodium glutamate (MSG) and composed the F1 generation, while control rats (CONT) received saline. At 90 days, male F1 were mated with non-obese females to obtain male offspring (F2), which later mated with non-obese females for obtaining male offspring of F3 generation. Lee Index analysis was adopted to set up the obesity groups. Alternating current biosusceptometry (ACB) technique was employed to calculate GI transit parameters: mean gastric emptying time (MGET), mean cecum arrival time (MCAT), mean small intestinal transit time (MSITT), and gastric frequency and amplitude of contractions. Glucose, insulin, and leptin levels and duodenal morphometry were measured. F1 obese rats showed a decrease in the frequency and amplitude of gastric contractions, while obese rats from the F2 generation showed accelerated MGET and delayed MCAT and MSITT. Glucose and leptin levels were increased in F1 and F2 generations. Insulin levels decreased in F1, F2, and F3 generations. Duodenal morphometry was altered in all three generations. Obesity may have paternal transgenerational transmission, and it provoked disturbances in the gastrointestinal function of three generations. |
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| المشرفين على المادة: | 0 (Insulin) 0 (Leptin) |
| تواريخ الأحداث: | Date Created: 20210602 Date Completed: 20210603 Latest Revision: 20220531 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8186378 |
| DOI: | 10.1590/1414-431X2020e11116 |
| PMID: | 34076145 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1414-431X |
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| DOI: | 10.1590/1414-431X2020e11116 |