دورية أكاديمية
Prevalence and outcome of isoniazid-monoresistant tuberculosis at a university hospital in Saudi Arabia.
| العنوان: | Prevalence and outcome of isoniazid-monoresistant tuberculosis at a university hospital in Saudi Arabia. |
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| المؤلفون: | Binkhamis KM; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Bahatheg MA; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Altahan FA; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Alwakeel SS; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Almutairi KA; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Alsaeed AF; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Alkadi DA; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Alshafai HA; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Almajid FM; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia., Barry MA; From the Department of Pathology (Binkhamis, Alkadi, Alshafai), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from the Infectious Diseases Unit, Department of Medicine (Almajid, Barry), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; from King Saud University Medical City (Binkhamis, Alkadi, Alshafai, Almajid, Barry), King Saud University, Riyadh, Kingdom of Saudi Arabia; from the College of Medicine (Bahatheg, Altahan, Alwakeel, Almutairi, Alsaeed), King Saud University, Riyadh, Kingdom of Saudi Arabia. |
| المصدر: | Saudi medical journal [Saudi Med J] 2021 Jun; Vol. 42 (6), pp. 636-642. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Country of Publication: Saudi Arabia NLM ID: 7909441 Publication Model: Print Cited Medium: Internet ISSN: 1658-3175 (Electronic) Linking ISSN: 03795284 NLM ISO Abbreviation: Saudi Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Riyadh : Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Original Publication: Riyadh, Saudi Arabia, Riyadh Al-Kharj Hospital Programme. |
| مواضيع طبية MeSH: | Mycobacterium tuberculosis* , Tuberculosis*/drug therapy , Tuberculosis, Multidrug-Resistant*/drug therapy, Antitubercular Agents/therapeutic use ; Cross-Sectional Studies ; Drug Resistance, Bacterial ; Hospitals ; Humans ; Isoniazid/therapeutic use ; Microbial Sensitivity Tests ; Prevalence ; Retrospective Studies ; Saudi Arabia/epidemiology |
| مستخلص: | Objectives: To determine the prevalence and outcome in patients with isoniazid-monoresistant Mycobacterium tuberculosis complex and compare them to those in patients with non-isoniazid-monoresistant Mycobacterium tuberculosis . Methods: This cross-sectional analytical study was conducted at King Khalid University Hospital, Riyadh, Saudi Arabia. The data were retrospectively collected from the electronic medical records of patients who tested positive for Mycobacterium tuberculosis between May 2015 and April 2019. Results: We identified 105 patients infected with Mycobacterium tuberculosis . The prevalence proportion of isoniazid-monoresistant tuberculosis was 8.6% (n=9). Five patients with isoniazid-monoresistant tuberculosis (55.6%) were successfully treated, while one patient died. In the nonresistant population, 51 (53.1%) patients were successfully treated. However, 12 (12.5%) patients with no isoniazid resistance had an unsuccessful treatment outcome. The resistant group had a longer treatment duration with a mean of 12 months compared to the non-isoniazid-resistant group, with a mean treatment duration of 9.5 months. Twenty-eight patients (26.7%) had adverse events, with the majority of them being in the non-isoniazid-resistant group. Conclusion: Isoniazid monoresistance is the most common form of drug resistance found in our population. Our study has not shown any significance in the outcome of isoniazid-resistant cases compared to non-isoniazid-resistant cases. This may be due to the low number of isoniazid-monoresistant cases in our population. (Copyright: © Saudi Medical Journal.) |
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| فهرسة مساهمة: | Keywords: Mycobacterium tuberculosis; drug resistance; isoniazid; patient outcome assessment; prevalence |
| المشرفين على المادة: | 0 (Antitubercular Agents) V83O1VOZ8L (Isoniazid) |
| تواريخ الأحداث: | Date Created: 20210603 Date Completed: 20210818 Latest Revision: 20220716 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9149726 |
| DOI: | 10.15537/smj.2021.42.6.20200832 |
| PMID: | 34078725 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1658-3175 |
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| DOI: | 10.15537/smj.2021.42.6.20200832 |