دورية أكاديمية
أعرض في EDS

Initial experience with del Nido cardioplegia solution at a Pediatric and Congenital Cardiac Surgery Program in Brazil.

التفاصيل البيبلوغرافية
العنوان: Initial experience with del Nido cardioplegia solution at a Pediatric and Congenital Cardiac Surgery Program in Brazil.
المؤلفون: Caneo LF; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Matte GS; Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA., R Turquetto AL; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Pegollo LMC; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Amato Miglioli MC; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., T de Souza G; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Amato LP; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Miana LA; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., B Massoti MR; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Penha JG; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Tanamati C; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Jatene MB; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil., Jatene FB; Pediatric Cardiovascular Surgery Unit, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InCor-HC-FMUSP), São Paulo, Brazil.
المصدر: Perfusion [Perfusion] 2022 Oct; Vol. 37 (7), pp. 684-691. Date of Electronic Publication: 2021 Jun 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 8700166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-111X (Electronic) Linking ISSN: 02676591 NLM ISO Abbreviation: Perfusion Subsets: MEDLINE
أسماء مطبوعة: Publication: London : SAGE Publications
Original Publication: [London] : Edward Arnold, [c1986-
مواضيع طبية MeSH: Cardiac Surgical Procedures* , Heart Defects, Congenital*/surgery , Ventricular Dysfunction*/drug therapy, Brazil ; Cardiac Output, Low ; Cardioplegic Solutions/therapeutic use ; Child ; Electrolytes ; Heart Arrest, Induced/methods ; Humans ; Lactates ; Lidocaine ; Magnesium Sulfate ; Mannitol ; Potassium Chloride ; Retrospective Studies ; Sodium Bicarbonate ; Solutions
مستخلص: Objective: The aim of this study was to evaluate outcome measures between our standard multidose cardioplegia protocol and a del Nido cardioplegia protocol in congenital heart surgery patients.
Methods: Retrospective single-center study including 250 consecutive patients that received del Nido cardioplegia (DN group) with a mandatory reperfusion period of 30% of cross clamp time and 250 patients that received a modified St. Thomas' solution (ST group). Groups were matched by age, weight, gender, and Risk Adjustment for Congenital Heart Surgery (RACHS-1) scores. Preoperative hematocrit and oxygen saturation were also recorded. Outcomes analyzed were the vasoactive inotropic score (VIS), lactate, ventilation time, ventricular dysfunction with low cardiac output syndrome (LCOS), intensive care unit (ICU) length of stay (LOS), hospital LOS, bypass and aortic cross-clamp times, and in-hospital mortality.
Results: Both groups were comparable demographically. Statistically significant differences (p ⩽ 0.05) were noted for cardiac dysfunction with LCOS, hematocrit at end of surgery (p = 0.0038), VIS on ICU admission and at end of surgery (p = 0.0111), and ICU LOS (p = 0.00118) with patients in the DN group having more desirable values for those parameters. Other outcome measures did not reach statistical significance.
Conclusion: In our congenital cardiac surgery population, del Nido cardioplegia strategy was associated with less ventricular dysfunction with LCOS, a lower VIS and decreased ICU LOS compared with patients that received our standard myocardial protection using a modified St. Thomas' solution. Despite the limitation of this study, including its retrospective nature and cohort size, these data supported our transition to incorporate del Nido cardioplegia solution with a mandatory reperfusion period as the preferred myocardial protection method in our program.
فهرسة مساهمة: Keywords: cardioplegia; congenital heart surgery; del Nido cardioplegia; myocardial protection and ventricular dysfunction; pediatrics; perfusion
المشرفين على المادة: 0 (Cardioplegic Solutions)
0 (Del Nido cardioplegia solution)
0 (Electrolytes)
0 (Lactates)
0 (Solutions)
3OWL53L36A (Mannitol)
660YQ98I10 (Potassium Chloride)
7487-88-9 (Magnesium Sulfate)
8MDF5V39QO (Sodium Bicarbonate)
98PI200987 (Lidocaine)
تواريخ الأحداث: Date Created: 20210603 Date Completed: 20220923 Latest Revision: 20221103
رمز التحديث: 20221213
DOI: 10.1177/02676591211020471
PMID: 34080462
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-111X
DOI:10.1177/02676591211020471