دورية أكاديمية
Sex differences in systemic bone and muscle loss following femur fracture in mice.
العنوان: | Sex differences in systemic bone and muscle loss following femur fracture in mice. |
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المؤلفون: | Osipov B; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Paralkar MP; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Emami AJ; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Cunningham HC; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Tjandra PM; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Pathak S; Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, USA., Langer HT; Department of Physiology and Membrane Biology, University of California Davis, Davis, California, USA., Baar K; Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, USA.; Department of Physiology and Membrane Biology, University of California Davis, Davis, California, USA., Christiansen BA; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA. |
المصدر: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2022 Apr; Vol. 40 (4), pp. 878-890. Date of Electronic Publication: 2021 Jun 13. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8404726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-527X (Electronic) Linking ISSN: 07360266 NLM ISO Abbreviation: J Orthop Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2006- : Hoboken, NJ : Wiley Original Publication: New York, N.Y. : Raven Press, [c1983- |
مواضيع طبية MeSH: | Bone Diseases, Metabolic* , Femoral Fractures*/complications , Sex Characteristics*, Animals ; Bone Density ; Female ; Femur/metabolism ; Femur/pathology ; Interleukin-1beta ; Interleukin-6 ; Male ; Mice ; Mice, Inbred C57BL ; Muscles/metabolism ; Muscles/pathology ; Tumor Necrosis Factor-alpha |
مستخلص: | Fracture induces systemic bone loss in mice and humans, and a first (index) fracture increases the risk of future fracture at any skeletal site more in men than women. The etiology of this sex difference is unknown, but fracture may induces a greater systemic bone loss response in men. Also sex differences in systemic muscle loss after fracture have not been examined. We investigated sex differences in systemic bone and muscle loss after transverse femur fracture in 3-month-old male and female C57BL/6 J mice. Whole-body and regional bone mineral content and density (BMC and BMD), trabecular and cortical bone microstructure, muscle contractile force, muscle mass, and muscle fiber size were quantified at multiple time points postfracture. Serum concentrations of inflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured 1-day postfracture. One day postfracture, IL-6 and Il-1B were elevated in fracture mice of both sexes, but TNF-α was only elevated in male fracture mice. Fracture reduced BMC, BMD, and trabecular bone microstructural properties in both sexes 2 weeks postfracture, but declines were greater in males. Muscle contractile force, mass, and fiber size decreased primarily in the fractured limb at 2 weeks postfracture and females showed a trend toward greater muscle loss. Bone and muscle properties recovered by 6 weeks postfracture. Overall, postfracture systemic bone loss is greater in men, which may contribute to sex differences in subsequent fracture risk. In both sexes, muscle loss is primarily confined to the injured limb and fracture may induce greater inflammation in males. (© 2021 Orthopaedic Research Society. Published by Wiley Periodicals LLC.) |
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معلومات مُعتمدة: | UL1 TR001860 United States TR NCATS NIH HHS; TL1 TR001861 United States TR NCATS NIH HHS; R01 AR071459 United States AR NIAMS NIH HHS; U24 DK092993 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: fracture; muscle; sex; systemic bone loss |
المشرفين على المادة: | 0 (IL1B protein, mouse) 0 (Interleukin-1beta) 0 (Interleukin-6) 0 (Tumor Necrosis Factor-alpha) |
تواريخ الأحداث: | Date Created: 20210603 Date Completed: 20220418 Latest Revision: 20230402 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8639826 |
DOI: | 10.1002/jor.25116 |
PMID: | 34081357 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1554-527X |
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DOI: | 10.1002/jor.25116 |