دورية أكاديمية
أعرض في EDS

Sex differences in systemic bone and muscle loss following femur fracture in mice.

التفاصيل البيبلوغرافية
العنوان: Sex differences in systemic bone and muscle loss following femur fracture in mice.
المؤلفون: Osipov B; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Paralkar MP; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Emami AJ; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Cunningham HC; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Tjandra PM; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA., Pathak S; Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, USA., Langer HT; Department of Physiology and Membrane Biology, University of California Davis, Davis, California, USA., Baar K; Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, USA.; Department of Physiology and Membrane Biology, University of California Davis, Davis, California, USA., Christiansen BA; Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA.
المصدر: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2022 Apr; Vol. 40 (4), pp. 878-890. Date of Electronic Publication: 2021 Jun 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8404726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-527X (Electronic) Linking ISSN: 07360266 NLM ISO Abbreviation: J Orthop Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : Hoboken, NJ : Wiley
Original Publication: New York, N.Y. : Raven Press, [c1983-
مواضيع طبية MeSH: Bone Diseases, Metabolic* , Femoral Fractures*/complications , Sex Characteristics*, Animals ; Bone Density ; Female ; Femur/metabolism ; Femur/pathology ; Interleukin-1beta ; Interleukin-6 ; Male ; Mice ; Mice, Inbred C57BL ; Muscles/metabolism ; Muscles/pathology ; Tumor Necrosis Factor-alpha
مستخلص: Fracture induces systemic bone loss in mice and humans, and a first (index) fracture increases the risk of future fracture at any skeletal site more in men than women. The etiology of this sex difference is unknown, but fracture may induces a greater systemic bone loss response in men. Also sex differences in systemic muscle loss after fracture have not been examined. We investigated sex differences in systemic bone and muscle loss after transverse femur fracture in 3-month-old male and female C57BL/6 J mice. Whole-body and regional bone mineral content and density (BMC and BMD), trabecular and cortical bone microstructure, muscle contractile force, muscle mass, and muscle fiber size were quantified at multiple time points postfracture. Serum concentrations of inflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured 1-day postfracture. One day postfracture, IL-6 and Il-1B were elevated in fracture mice of both sexes, but TNF-α was only elevated in male fracture mice. Fracture reduced BMC, BMD, and trabecular bone microstructural properties in both sexes 2 weeks postfracture, but declines were greater in males. Muscle contractile force, mass, and fiber size decreased primarily in the fractured limb at 2 weeks postfracture and females showed a trend toward greater muscle loss. Bone and muscle properties recovered by 6 weeks postfracture. Overall, postfracture systemic bone loss is greater in men, which may contribute to sex differences in subsequent fracture risk. In both sexes, muscle loss is primarily confined to the injured limb and fracture may induce greater inflammation in males.
(© 2021 Orthopaedic Research Society. Published by Wiley Periodicals LLC.)
References: Trends Endocrinol Metab. 2012 Nov;23(11):576-81. (PMID: 22595550)
Curr Osteoporos Rep. 2017 Feb;15(1):18-23. (PMID: 28161871)
J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1226-35. (PMID: 22923429)
J Leukoc Biol. 2004 Jul;76(1):36-41. (PMID: 14761938)
Arthritis Rheum. 2013 Sep;65(9):2262-73. (PMID: 23784528)
Best Pract Res Clin Endocrinol Metab. 2013 Aug;27(4):527-39. (PMID: 24054929)
Arch Surg. 1998 Nov;133(11):1200-5. (PMID: 9820351)
J Orthop Res. 1984;2(1):97-101. (PMID: 6491805)
Best Pract Res Clin Endocrinol Metab. 2018 Oct;32(5):759-772. (PMID: 30449553)
Shock. 2008 Jul;30(1):43-7. (PMID: 18562923)
J Bone Miner Res. 2007 Mar;22(3):465-75. (PMID: 17144789)
Clin Rev Bone Miner Metab. 2018 Dec;16(4):116-130. (PMID: 31363348)
Pharmacol Ther. 2007 Mar;113(3):461-87. (PMID: 17258813)
Surgery. 2010 Jan;147(1):134-7. (PMID: 20082798)
Osteoporos Int. 2004 Mar;15(3):175-9. (PMID: 14691617)
Arch Intern Med. 2002 Jan 14;162(1):33-6. (PMID: 11784217)
J Bone Miner Res. 2019 Jan;34(1):157-170. (PMID: 30189111)
Mediators Inflamm. 2012;2012:890816. (PMID: 22481866)
J Bone Joint Surg Am. 2003 Oct;85(10):1936-43. (PMID: 14563801)
J Nutr. 2015 May;145(5):900-6. (PMID: 25740910)
Biomedicines. 2017 Oct 24;5(4):. (PMID: 29064421)
Osteoporos Int. 2019 Mar;30(3):541-553. (PMID: 30610245)
Eur J Med Res. 2017 Jul 6;22(1):23. (PMID: 28683813)
Biomed Res Int. 2016;2016:9089610. (PMID: 26977415)
Curr Osteoporos Rep. 2018 Apr;16(2):138-145. (PMID: 29508143)
PLoS One. 2012;7(12):e51457. (PMID: 23251540)
Blood. 2011 Nov 24;118(22):5918-27. (PMID: 21911834)
Skelet Muscle. 2014 Nov 27;4:21. (PMID: 25937889)
J Orthop Sci. 2020 Mar;25(2):338-343. (PMID: 31031109)
J Bone Joint Surg Br. 2000 Apr;82(3):326-31. (PMID: 10813163)
Age Ageing. 2012 Mar;41(2):171-7. (PMID: 22232302)
Zoolog Sci. 2013 Dec;30(12):1019-24. (PMID: 24320179)
Osteoporos Int. 2000;11(1):31-5. (PMID: 10663356)
J Bone Joint Surg Am. 2002 Sep;84(9):1528-33. (PMID: 12208908)
J Orthop Res. 2012 Nov;30(11):1853-9. (PMID: 22592891)
J Bone Miner Res. 1996 Aug;11(8):1043-51. (PMID: 8854239)
Sci Rep. 2016 Oct 31;6:36330. (PMID: 27796345)
Osteoporos Int. 2018 Oct;29(10):2201-2209. (PMID: 29992510)
J Bone Miner Res. 2010 Jul;25(7):1468-86. (PMID: 20533309)
Bone. 2016 May;86:119-30. (PMID: 26946132)
Acta Physiol (Oxf). 2014 Mar;210(3):600-11. (PMID: 24168489)
Shock. 2005 Jul;24(1):74-84. (PMID: 15988324)
J Bone Miner Res. 2013 Aug;28(8):1751-9. (PMID: 23456800)
Curr Rheumatol Rep. 2008 Oct;10(5):413-7. (PMID: 18817647)
Nat Rev Drug Discov. 2012 Mar 01;11(3):234-50. (PMID: 22378270)
Biol Sex Differ. 2019 Aug 28;10(1):43. (PMID: 31462271)
J Bone Miner Res. 2015 Jun;30(6):951-66. (PMID: 25917136)
Gait Posture. 2020 Mar;77:207-213. (PMID: 32058285)
Cytokine. 2001 May 7;14(3):162-9. (PMID: 11396994)
معلومات مُعتمدة: UL1 TR001860 United States TR NCATS NIH HHS; TL1 TR001861 United States TR NCATS NIH HHS; R01 AR071459 United States AR NIAMS NIH HHS; U24 DK092993 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: fracture; muscle; sex; systemic bone loss
المشرفين على المادة: 0 (IL1B protein, mouse)
0 (Interleukin-1beta)
0 (Interleukin-6)
0 (Tumor Necrosis Factor-alpha)
تواريخ الأحداث: Date Created: 20210603 Date Completed: 20220418 Latest Revision: 20230402
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8639826
DOI: 10.1002/jor.25116
PMID: 34081357
قاعدة البيانات: MEDLINE
الوصف
تدمد:1554-527X
DOI:10.1002/jor.25116