التفاصيل البيبلوغرافية
| العنوان: |
Sex Differences in Respiratory Viral Pathogenesis and Treatments. |
| المؤلفون: |
Ursin RL; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA 21205; email: sklein2@jhu.edu., Klein SL; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA 21205; email: sklein2@jhu.edu.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA 21205. |
| المصدر: |
Annual review of virology [Annu Rev Virol] 2021 Sep 29; Vol. 8 (1), pp. 393-414. Date of Electronic Publication: 2021 Jun 03. |
| نوع المنشور: |
Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Annual Reviews Country of Publication: United States NLM ID: 101625721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2327-0578 (Electronic) Linking ISSN: 2327056X NLM ISO Abbreviation: Annu Rev Virol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Palo Alto, California : Annual Reviews, 2014- |
| مواضيع طبية MeSH: |
Virus Physiological Phenomena*, Respiratory Tract Infections/*epidemiology , Respiratory Tract Infections/*therapy, Age Factors ; Animals ; Female ; Humans ; Male ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/virology ; Severity of Illness Index ; Sex Characteristics ; Sex Factors ; Viruses/classification |
| مستخلص: |
Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 differs between the sexes across the life course. Generally, males are more susceptible to severe outcomes from respiratory viral infections at younger and older ages. During reproductive years (i.e., after puberty and prior to menopause), females are often at greater risk than males for severe outcomes. Pregnancy and biological sex affect the pathogenesis of respiratory viral infections. In addition to sex differences in the pathogenesis of disease, there are consistent sex differences in responses to treatments, with females often developing greater immune responses but experiencing more adverse reactions than males. Animal models provide mechanistic insights into the causes of sex differences in respiratory virus pathogenesis and treatment outcomes, where available. |
| معلومات مُعتمدة: |
U54 CA260492 United States CA NCI NIH HHS |
| فهرسة مساهمة: |
Keywords: COVID-19; RSV; SARS-CoV-2; gender difference; influenza; vaccines |
| تواريخ الأحداث: |
Date Created: 20210603 Date Completed: 20211004 Latest Revision: 20220716 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1146/annurev-virology-091919-092720 |
| PMID: |
34081540 |
| قاعدة البيانات: |
MEDLINE |
