دورية أكاديمية
أعرض في EDS

The role of demethylases in cardiac development and disease.

التفاصيل البيبلوغرافية
العنوان: The role of demethylases in cardiac development and disease.
المؤلفون: Davis K; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America. Electronic address: kat.davis@utah.edu., Azarcon P; School of Medicine, University of Utah, Salt Lake City, UT, United States of America., Hickenlooper S; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America., Bia R; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America., Horiuchi E; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America., Szulik MW; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America., Franklin S; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States of America. Electronic address: sarah.franklin@utah.edu.
المصدر: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2021 Sep; Vol. 158, pp. 89-100. Date of Electronic Publication: 2021 May 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, New York, Academic Press.
مواضيع طبية MeSH: Heart/*growth & development , Heart Failure/*enzymology , Jumonji Domain-Containing Histone Demethylases/*metabolism , Myocardium/*enzymology, Adult ; Animals ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly/genetics ; Enzyme Inhibitors/therapeutic use ; Epigenesis, Genetic ; Heart Failure/drug therapy ; Heart Failure/genetics ; Histones/metabolism ; Humans ; Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors ; Lysine/metabolism ; Methylation ; Protein Processing, Post-Translational
مستخلص: Heart failure is a worldwide health condition that currently has limited noninvasive treatments. Heart disease includes both structural and molecular remodeling of the heart which is driven by alterations in gene expression in the cardiomyocyte. Therefore, understanding the regulatory mechanisms which instigate these changes in gene expression and constitute the foundation for pathological remodeling may be beneficial for developing new treatments for heart disease. These gene expression changes are largely preceded by epigenetic alterations to chromatin, including the post-translational modification of histones such as methylation, which alters chromatin to be more or less accessible for transcription factors or regulatory proteins to bind and modify gene expression. Methylation was once thought to be a permanent mark placed on histone or non-histone targets by methyltransferases, but is now understood to be a reversible process after the discovery of the first demethylase, KDM1A/LSD1. Since this time, it has been shown that demethylases play key roles in embryonic development, in maintaining cellular homeostasis and disease progression. However, the role of demethylases in the fetal and adult heart remains largely unknown. In this review, we have compiled data on the 33 mammalian demethylases that have been identified to date and evaluate their expression in the embryonic and adult heart as well as changes in expression in the failing myocardium using publicly available RNA-sequencing and proteomic datasets. Our analysis detected expression of 14 demethylases in the normal fetal heart, and 5 demethylases in the normal adult heart. Moreover, 8 demethylases displayed differential expression in the diseased human heart compared to healthy hearts. We then examined the literature regarding these demethylases and provide phenotypic information of 13 demethylases that have been functionally interrogated in some way in the heart. Lastly, we describe the 6 arginine and lysine residues on histones which have been shown to be methylated but have no corresponding demethylase identified which removes these methyl marks. Overall, this review highlights our current knowledge on the role of demethylases, their importance in cardiac development and pathophysiology and provides evidence for the use of pharmacological inhibitors to combat disease.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Demethylase; Epigenetics; Heart development; Heart disease; Histone methylation; Post-translational modification; Transcriptional regulation
المشرفين على المادة: 0 (Chromatin)
0 (Enzyme Inhibitors)
0 (Histones)
EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
K3Z4F929H6 (Lysine)
تواريخ الأحداث: Date Created: 20210603 Date Completed: 20220128 Latest Revision: 20220128
رمز التحديث: 20240628
DOI: 10.1016/j.yjmcc.2021.05.018
PMID: 34081951
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-8584
DOI:10.1016/j.yjmcc.2021.05.018