دورية أكاديمية
Incidence and prevalence of epilepsy and associated factors in a health district in North-West Cameroon: A population survey.
| العنوان: | Incidence and prevalence of epilepsy and associated factors in a health district in North-West Cameroon: A population survey. |
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| المؤلفون: | Angwafor SA; NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG and Chalfont Centre for Epilepsy, Chalfont St Peter, Bucks SL9 0RJ, United Kingdom; Faculty of Health Sciences, University of Bamenda, Cameroon., Bell GS; NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG and Chalfont Centre for Epilepsy, Chalfont St Peter, Bucks SL9 0RJ, United Kingdom., Ngarka L; Neurology Department, Central Hospital Yaoundé/Faculty of Medicine and Biomedical Sciences (FMBS), The University of Yaoundé I, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon/Geneva, Switzerland., Otte W; Department of Pediatric Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Tabah EN; Department of Public Health, Faculty of Medicine and Biomedical Sciences, University Of Dschang, Cameroon & Department of Disease Control, Ministry of Public Health, Yaounde, Cameroon., Nfor LN; Neurology Department, Central Hospital Yaoundé/Faculty of Medicine and Biomedical Sciences (FMBS), The University of Yaoundé I, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon/Geneva, Switzerland., Njamnshi TN; Department of Medical Laboratory Science, School of Health and Medical Science, Kumbo, Catholic University of Cameroon, Bamenda, Cameroon., Njamnshi AK; Neurology Department, Central Hospital Yaoundé/Faculty of Medicine and Biomedical Sciences (FMBS), The University of Yaoundé I, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon/Geneva, Switzerland. Electronic address: alfred.njamnshi@brainafrica.org., Sander JW; NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG and Chalfont Centre for Epilepsy, Chalfont St Peter, Bucks SL9 0RJ, United Kingdom; Stichting Epilepsie Instelligen Nederland (SEIN), Heemstede, Netherlands. |
| المصدر: | Epilepsy & behavior : E&B [Epilepsy Behav] 2021 Aug; Vol. 121 (Pt A), pp. 108048. Date of Electronic Publication: 2021 Jun 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Diego, CA : Academic Press, c2000- |
| مواضيع طبية MeSH: | Epilepsy*/epidemiology, Adult ; Cameroon/epidemiology ; Case-Control Studies ; Cross-Sectional Studies ; Humans ; Incidence ; Prevalence ; Rural Population |
| مستخلص: | This population-based cross-sectional survey with a follow-up case-control study assessed the prevalence, incidence, and risk factors for epilepsy in a rural health district in the North-West Region of Cameroon. Community-based epilepsy screening targeted all inhabitants, six years and older, in all 16 health areas in the Batibo Health District. During door-to-door visits, trained fieldworkers used a validated questionnaire to interview consenting household heads to screen for epilepsy in eligible residents. Trained physicians subsequently assessed people with suspected seizures. After clinical assessment, they confirmed or refuted the diagnosis and estimated the date of epilepsy onset. A trained nurse interviewed people with epilepsy and randomly selected healthy individuals, obtaining relevant demographic details and information on exposure to risk factors for epilepsy. Out of 36,282 residents screened, 524 had active epilepsy. The age-standardized prevalence of active epilepsy was 33.9/1,000 (95% CI: 31.0-37.1/1,000). We estimated the one-year age-standardized epilepsy incidence at 171/100,000 (95%CI: 114.0-254.6). Active epilepsy prevalence varied widely between health areas, ranging between 12 and 75 per 1,000. The peak age-specific prevalence was in the 25-34 age group. In adults, multivariate analysis showed that having a relative with epilepsy was positively associated with epilepsy. Epilepsy characteristics in this population, geographical heterogeneity, and the age-specific prevalence pattern suggest that endemic neurocysticercosis and onchocerciasis may be implicated. Further investigations are warranted to establish the full range of risk factors for epilepsy in this population. Competing Interests: Declaration of Competing Interest JWS receives research support from the Dr Marvin Weil Epilepsy Research Fund, the UK Epilepsy Society and the Christelijke Vereniging voor de Verpleging van Lijdersaan Epilepsie, The Netherlands. GSB and her husband have shares in GlaxoSmithKline which manufactures anti-epileptic drugs. All other authors have no conflicts of interest to declare. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Batibo; Epidemiology; Parasitic diseases; Risk factors; Seizures |
| تواريخ الأحداث: | Date Created: 20210604 Date Completed: 20210630 Latest Revision: 20210630 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.yebeh.2021.108048 |
| PMID: | 34083120 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1525-5069 |
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| DOI: | 10.1016/j.yebeh.2021.108048 |