دورية أكاديمية
NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving.
العنوان: | NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving. |
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المؤلفون: | Pu ZQ; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Yu TF; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Liu D; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Jin CW; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Sadiq E; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Qiao X; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Li X; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Chen Y; Department of Cell Biology, Shandong University School of Medicine, Jinan, China., Zhang J; Shandong University School of Medicine, Jinan, China., Tian M; Laboratory of Human Genetics, Shandong Provincial Hospital (Dongying Branch), Affiliated to Shandong University, Dongying, China., Li S; Shandong University School of Medicine, Jinan, China., Zhao RX; Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China. zhaoruxing@qiluhospital.com., Wang XD; Department of Cell Biology, Shandong University School of Medicine, Jinan, China. xdongw@sdu.edu.cn.; Shandong University School of Medicine, Jinan, China. xdongw@sdu.edu.cn. |
المصدر: | Cell death discovery [Cell Death Discov] 2021 Jun 04; Vol. 7 (1), pp. 133. Date of Electronic Publication: 2021 Jun 04. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [New York, NY] : Nature Publishing Group, [2015]- |
مستخلص: | Under adverse conditions, such as sustained or chronic hyperglycemia or hyperlipidemia, ROS (reactive oxygen species) or/and ER-stress (endoplasmic reticulum stress) will be induced in pancreatic β cells. ROS or ER-stress damages β-cells even leads to apoptosis. Previously we found ROS or ER-stress resulted in JNK activation in β cells and overexpressing NR4A1 in MIN6 cells reduced JNK activation via modulating cbl-b expression and subsequent degrading the upstream JNK kinase (MKK4). To search other possible mechanisms, we found the mRNA level and protein level of MKP7 (a phosphatase for phospho-JNK) were dramatic reduced in pancreatic β cells in the islets from NR4A1 KO mice compared with that from wild type mice. To confirm what we found in animals, we applied pancreatic β cells (MIN6 cells) and found that the expression of MKP7 was increased in NR4A1-overexpression MIN6 cells. We further found that knocking down the expression of MKP7 increased the p-JNK level in pancreatic β cells upon treatment with TG or H |
References: | Mol Cell Biol. 1993 Oct;13(10):6124-36. (PMID: 8413214) Neuron. 2003 Jun 19;38(6):899-914. (PMID: 12818176) Oncogene. 2003 Oct 30;22(49):7728-36. (PMID: 14586399) Gut. 2011 May;60(5):648-57. (PMID: 21199832) Oxid Med Cell Longev. 2016;2016:4137908. (PMID: 26881026) Diabetes. 2012 Apr;61(4):838-47. (PMID: 22362176) J Biol Chem. 2010 Jul 9;285(28):21581-9. (PMID: 20430894) Cell Death Differ. 2014 Apr;21(4):612-23. (PMID: 24413150) Cell Death Differ. 2009 Nov;16(11):1539-50. (PMID: 19629134) J Cell Biochem. 2018 Jul;119(7):5143-5152. (PMID: 29143999) Endocrinology. 2008 Apr;149(4):1654-65. (PMID: 18187551) Cell Res. 2008 Aug;18(8):879-88. (PMID: 18663379) Basic Res Cardiol. 2004 Sep;99(5):338-50. (PMID: 15309413) Biochem Biophys Res Commun. 2020 Mar 26;524(1):142-149. (PMID: 31982140) Autophagy. 2013 Sep;9(9):1292-307. (PMID: 23800749) Nanotoxicology. 2019 Apr;13(3):369-391. (PMID: 30729847) Cancer Metastasis Rev. 2008 Jun;27(2):253-61. (PMID: 18330678) Mol Nutr Food Res. 2015 Nov;59(11):2293-302. (PMID: 26304773) Nano Lett. 2020 Mar 11;20(3):1928-1933. (PMID: 32073871) Biomaterials. 2017 Nov;146:72-85. (PMID: 28898759) Trends Endocrinol Metab. 2010 Dec;21(12):707-13. (PMID: 20888782) ACS Nano. 2015 Mar 24;9(3):2584-99. (PMID: 25692960) Autophagy. 2020 May 20;:1-22. (PMID: 32432943) Nano Lett. 2020 May 13;20(5):3943-3955. (PMID: 32243175) Cell Death Differ. 2017 Sep;24(9):1530-1539. (PMID: 28622293) Cell Death Differ. 2013 Oct;20(10):1317-29. (PMID: 23832115) J Cell Mol Med. 2020 Dec;24(24):14171-14183. (PMID: 33124187) J Hepatol. 2012 Jan;56(1):17-9. (PMID: 21703172) Clin Cancer Res. 2012 Jun 15;18(12):3223-8. (PMID: 22566377) Cell Death Differ. 2015 May;22(5):862-74. (PMID: 25361078) J Biol Chem. 2015 Aug 21;290(34):20687-20699. (PMID: 26157144) Metabolism. 2016 Oct;65(10):1570-81. (PMID: 27621192) Oxid Med Cell Longev. 2019 Sep 5;2019:9836302. (PMID: 31583053) Acta Biomater. 2020 Jun;109:229-243. (PMID: 32294550) Cancer Lett. 2018 Sep 1;431:31-42. (PMID: 29807112) Cardiovasc Res. 2005 Feb 15;65(3):609-18. (PMID: 15664387) Cell Signal. 2017 Jul;35:129-139. (PMID: 28342843) J Control Release. 2020 Mar 10;319:119-134. (PMID: 31883459) Cell. 2011 Sep 30;147(1):173-84. (PMID: 21962514) Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21732-21738. (PMID: 31594848) Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23743-23752. (PMID: 31685635) Blood. 2009 Apr 23;113(17):4038-48. (PMID: 19074726) Biomed Pharmacother. 2019 Apr;112:108672. (PMID: 30784940) Proc Natl Acad Sci U S A. 1988 Nov;85(22):8444-8. (PMID: 3186734) J Clin Invest. 2004 Dec;114(12):1752-61. (PMID: 15599400) Nature. 2003 May 29;423(6939):555-60. (PMID: 12774125) |
تواريخ الأحداث: | Date Created: 20210605 Latest Revision: 20210608 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8178316 |
DOI: | 10.1038/s41420-021-00521-0 |
PMID: | 34088892 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2058-7716 |
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DOI: | 10.1038/s41420-021-00521-0 |