دورية أكاديمية
أعرض في EDS

Gestational thrombocytopenia: a case-control study of over 3,500 pregnancies.

التفاصيل البيبلوغرافية
العنوان: Gestational thrombocytopenia: a case-control study of over 3,500 pregnancies.
المؤلفون: Fogerty AE; Medicine, Massachusetts General Hospital, Boston, MA, USA., Dzik W; Pathology, Massachusetts General Hospital, Boston, MA, USA.
المصدر: British journal of haematology [Br J Haematol] 2021 Jul; Vol. 194 (2), pp. 433-438. Date of Electronic Publication: 2021 Jun 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley-Blackwell
Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: Pregnancy Complications, Hematologic/*blood , Thrombocytopenia/*blood, Adult ; Blood Platelets/pathology ; Case-Control Studies ; Female ; Humans ; Platelet Count ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Thrombocytopenia/diagnosis
مستخلص: Gestational thrombocytopenia (GT) affects an estimated nine million women annually. Women with GT have recurrent episodes on subsequent pregnancies suggesting that GT is related to a maternal factor rather than a factor unique to the individual pregnancy. We performed a case-control study of over 3 500 pregnancies at a single hospital during 2017. We defined GT as any pregnancy with a platelet count <150 000/µl during the 100 days prior to delivery. We excluded women with platelet counts <50 000/µl or with conditions known to cause thrombocytopenia. GT was present in 12% of pregnancies. The median platelet count at delivery was 134 500/µl in cases versus 208 000/µl in controls, P < 0·0001. During the pregnancy, the platelet count declined 31·8% in cases compared with 18·3% in controls (P < 0·0001) in association with a significant increase in mean platelet volume during each trimester. Among women with GT, platelet counts rapidly increased during the first week postpartum, consistent with a mechanism directly related to high blood flow rates in the gravid uterus. GT, a recurrent condition of at-risk women, is a common haematological disorder of pregnancy. Future research may focus on genetic gain-of-function polymorphisms resulting in increased turnover of platelets uncovered only during periods of high-shear blood flow.
(© 2021 British Society for Haematology and John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: platelet count; platelet physiology; pregnancy; thrombocytopenia
تواريخ الأحداث: Date Created: 20210609 Date Completed: 20211220 Latest Revision: 20211220
رمز التحديث: 20231215
DOI: 10.1111/bjh.17611
PMID: 34105146
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2141
DOI:10.1111/bjh.17611