دورية أكاديمية
Gestational thrombocytopenia: a case-control study of over 3,500 pregnancies.
العنوان: | Gestational thrombocytopenia: a case-control study of over 3,500 pregnancies. |
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المؤلفون: | Fogerty AE; Medicine, Massachusetts General Hospital, Boston, MA, USA., Dzik W; Pathology, Massachusetts General Hospital, Boston, MA, USA. |
المصدر: | British journal of haematology [Br J Haematol] 2021 Jul; Vol. 194 (2), pp. 433-438. Date of Electronic Publication: 2021 Jun 09. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
مواضيع طبية MeSH: | Pregnancy Complications, Hematologic/*blood , Thrombocytopenia/*blood, Adult ; Blood Platelets/pathology ; Case-Control Studies ; Female ; Humans ; Platelet Count ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Thrombocytopenia/diagnosis |
مستخلص: | Gestational thrombocytopenia (GT) affects an estimated nine million women annually. Women with GT have recurrent episodes on subsequent pregnancies suggesting that GT is related to a maternal factor rather than a factor unique to the individual pregnancy. We performed a case-control study of over 3 500 pregnancies at a single hospital during 2017. We defined GT as any pregnancy with a platelet count <150 000/µl during the 100 days prior to delivery. We excluded women with platelet counts <50 000/µl or with conditions known to cause thrombocytopenia. GT was present in 12% of pregnancies. The median platelet count at delivery was 134 500/µl in cases versus 208 000/µl in controls, P < 0·0001. During the pregnancy, the platelet count declined 31·8% in cases compared with 18·3% in controls (P < 0·0001) in association with a significant increase in mean platelet volume during each trimester. Among women with GT, platelet counts rapidly increased during the first week postpartum, consistent with a mechanism directly related to high blood flow rates in the gravid uterus. GT, a recurrent condition of at-risk women, is a common haematological disorder of pregnancy. Future research may focus on genetic gain-of-function polymorphisms resulting in increased turnover of platelets uncovered only during periods of high-shear blood flow. (© 2021 British Society for Haematology and John Wiley & Sons Ltd.) |
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فهرسة مساهمة: | Keywords: platelet count; platelet physiology; pregnancy; thrombocytopenia |
تواريخ الأحداث: | Date Created: 20210609 Date Completed: 20211220 Latest Revision: 20211220 |
رمز التحديث: | 20231215 |
DOI: | 10.1111/bjh.17611 |
PMID: | 34105146 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-2141 |
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DOI: | 10.1111/bjh.17611 |