دورية أكاديمية
Management of mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a kidney recipient: a case report.
| العنوان: | Management of mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a kidney recipient: a case report. |
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| المؤلفون: | Boix F; Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, Spain., Feito J; Department of Clinical Pathology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, Spain., Rodríguez-Campón A; Department of Nephrology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, Spain., Chillón MC; Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, Spain., García-Sánchez S; Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, Spain., Tabernero G; Department of Nephrology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, Spain., Fraile P; Department of Nephrology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, Spain., García-Sanz R; Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, Spain. |
| المصدر: | British journal of biomedical science [Br J Biomed Sci] 2021 Oct; Vol. 78 (4), pp. 244-247. Date of Electronic Publication: 2021 Aug 27. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 9309208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2474-0896 (Electronic) Linking ISSN: 09674845 NLM ISO Abbreviation: Br J Biomed Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Lausanne, Switzerland : Frontiers Media SA Original Publication: [London] : Published for the Institute of Medical Laboratory Sciences by Royal Society of Medicine Services, c1993- |
| مواضيع طبية MeSH: | Graft Rejection* , Isoantibodies*, CD8-Positive T-Lymphocytes ; HLA Antigens ; Humans ; Kidney |
| مستخلص: | Mixed acute rejection is a clinicopathological entity that is difficult to accurately diagnose, and so may be under-reported. Allografts are lost more often than in either humoral or cellular rejection. The diagnosis requires both histological and immunological studies on renal biopsy and blood specimens from the transplant recipient to provide the required rescue therapy to abolish the allogeneic response against the graft. We present a clinical case report of an active mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a patient with a kidney transplant. The patient was diagnosed, treated, and followed up as per the local institution's procedure with a full recovery of graft function. Our case emphasises the challenge of a mixed acute rejection and supports the need to improve the post-transplant outcome of recipients and their grafts. |
| فهرسة مساهمة: | Keywords: Antibody-mediated rejection; HLA; T-cell mediated rejection; complement binding; desensitization; donor specific antibodies; mixed acute rejection |
| المشرفين على المادة: | 0 (HLA Antigens) 0 (Isoantibodies) |
| تواريخ الأحداث: | Date Created: 20210609 Date Completed: 20220114 Latest Revision: 20220114 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/09674845.2021.1927308 |
| PMID: | 34105441 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 2474-0896 |
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| DOI: | 10.1080/09674845.2021.1927308 |