دورية أكاديمية
Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis.
| العنوان: | Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis. |
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| المؤلفون: | Eltom K; Department of Microbiology and Parasitology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.; Department of Virology, Central Laboratory, Ministry of Higher Education and Scientific Research, Khartoum, Sudan., Enan K; Department of Virology, Central Laboratory, Ministry of Higher Education and Scientific Research, Khartoum, Sudan., El Hussein ARM; Department of Virology, Central Laboratory, Ministry of Higher Education and Scientific Research, Khartoum, Sudan., Elkhidir IM; Department of Microbiology and Parasitology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan. |
| المصدر: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 May 25; Vol. 11, pp. 678945. Date of Electronic Publication: 2021 May 25 (Print Publication: 2021). |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA |
| مواضيع طبية MeSH: | Dengue*/epidemiology , Virus Diseases*, Africa South of the Sahara/epidemiology ; Cross-Sectional Studies ; Humans ; Prevalence |
| مستخلص: | Dengue virus (DENV) infection has garnered a global interest in the past few decades. Nevertheless, its epidemiology in certain developing and low-income regions remains poorly understood, due to the absence of comprehensive surveillance and reporting systems. This systematic review and meta-analysis aimed to determine the prevalence of DENV infection in the population of Sub-Saharan Africa using DENV infection markers, and to track any changes in its prevalence during the past ten years. It was conducted in accordance with the PRISMA guidelines, targeting the literature available at MEDLINE/PubMed, ScienceDirect, Cochrane library and Google Scholar. All articles published in English language between January 2010 and June 2020 were screened for eligibility. Random effects model was used to calculate the pooled prevalence of all infection markers. The Inconsistency Index ( I 2 ) was used to assess the level of heterogeneity between studies. Subgroup analysis according to country and time-frame of studies was conducted to provide possible explanations to substantial heterogeneity. The critical appraisal tool for prevalence studies designed by the Joanna Briggs Institute (JBI) was used to assess the risk of bias in all included studies. A total of 84 articles, covering 21 countries, were included in this review. Quantitative meta-analysis estimated a pooled IgG prevalence of 25% (95% CI: 21-29%, I 2 = 99%), a pooled IgM prevalence of 10% (95% CI: 9-11%, I 2 = 98%) and a pooled DENV RNA prevalence of 14% (95% CI: 12-16%, I 2 = 99%). Evidence for possible publication bias was also found in all three meta-analyses. Subgroup analysis according to the time of sample collection was performed to closely track the changing prevalence of DENV infection markers between 2010 and 2019. This meta-analysis estimates a high prevalence of DENV infection in Sub-Saharan Africa. More cost-efficient vector control strategies should be designed and implemented in order to adapt to the low-resource nature of this region. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Eltom, Enan, El Hussein and Elkhidir.) |
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| فهرسة مساهمة: | Keywords: Sub-Saharan Africa (SSA); dengue (DENV); epidemiology; meta-analysis; systematic review |
| تواريخ الأحداث: | Date Created: 20210611 Date Completed: 20210705 Latest Revision: 20210705 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8186319 |
| DOI: | 10.3389/fcimb.2021.678945 |
| PMID: | 34113579 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2235-2988 |
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| DOI: | 10.3389/fcimb.2021.678945 |