دورية أكاديمية
Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy and Safety of Fluvoxamine in Major Depressive Disorder.
العنوان: | Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy and Safety of Fluvoxamine in Major Depressive Disorder. |
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المؤلفون: | Zastrozhin M; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia.; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Skryabin V; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Smirnov V; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia; and.; NRC Institute of Immunology FMBA of Russia, Moscow, Russia., Zastrozhina A; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Grishina E; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Ryzhikova K; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Bure I; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Golovinskii P; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Koporov S; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Bryun E; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia.; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Sychev D; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. |
المصدر: | American journal of therapeutics [Am J Ther] 2021 Jun 03; Vol. 29 (1), pp. e26-e33. Date of Electronic Publication: 2021 Jun 03. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9441347 Publication Model: Electronic Cited Medium: Internet ISSN: 1536-3686 (Electronic) Linking ISSN: 10752765 NLM ISO Abbreviation: Am J Ther Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1998- : Philadelphia, PA : Lippincott Williams & Wilkins Original Publication: New York, NY : Chapman & Hall, c1994- |
مواضيع طبية MeSH: | Depressive Disorder, Major*/drug therapy , Depressive Disorder, Major*/genetics , MicroRNAs*, Cytochrome P-450 CYP2D6/genetics ; Fluvoxamine/adverse effects ; Genotype ; Humans ; Male ; Polymorphism, Genetic ; Tandem Mass Spectrometry |
مستخلص: | Background: Previous studies have shown that cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of fluvoxamine, the activity of which is highly dependent, inter alia, on the polymorphism of the gene encoding it. The objective of our study was to investigate the effect of 1846G>A polymorphism of the CYP2D6 gene on the efficacy and safety of fluvoxamine, using findings on CYP2D6 enzymatic activity and on CYP2D6 expression level in patients with depressive disorders comorbid with alcohol use disorder. Study Question: Efficacy and safety of fluvoxamine depend on the polymorphism of CYP2D6 gene in patients with major depressive disorder. Study Design: Our study enrolled 96 male patients with depressive disorders comorbid with alcohol use disorder. Patients were examined on days 1, 9, and 16 of fluvoxamine therapy. Measures and Outcomes: Treatment efficacy was evaluated using the validated psychometric scales. Therapy safety was assessed using the UKU Side-Effect Rating Scale. For genotyping and estimation of the microRNA (miRNA) plasma levels, we performed the real-time polymerase chain reaction. The activity of CYP2D6 was evaluated using the HPLC-MS/MS method by the content of the endogenous substrate of given isoenzyme and its metabolite in urine (6-hydroxy-1,2,3,4-tetrahydro-β-carboline/pinoline ratio). Results: Our study revealed the statistically significant results for the treatment efficacy evaluation [the Hamilton Depression Rating Scale scores at the end of the treatment course: (GG) 2.0 (1.0-4.0) and (GA) 5.0 (4.0-7.0), P < 0.001]. Analysis of the results of the pharmacotranscriptomic part of the study did not show the statistically significant difference in the hsa-miR-370-3p plasma levels in patients with different genotypes: (GG) 26.9 (15.0-32.2), (GA) 31.8 (22.7-33.7), P = 0.247. In addition, we evaluated the relationship between the CYP2D6 enzymatic activity (as evaluated by 6-hydroxy-1,2,3,4-tetrahydro-β-carboline/pinoline ratio measurement) and the hsa-miR-370-3p plasma concentration: rs = -0.243, P = 0.017. Conclusions: The effect of genetic polymorphism of the CYP2D6 gene on the efficacy and safety profiles of fluvoxamine was demonstrated in a group of 96 patients with depressive disorders comorbid with alcohol use disorder. Competing Interests: The authors have no conflicts of interest to declare. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.) |
References: | Agabio R, Trogu E, Pani PP. Antidepressants for the treatment of people with co‐occurring depression and alcohol dependence. Cochrane Database Syst Rev. 2018;4:CD008581. Pettinati HM, O'Brien CP, Dundon WD. Current status of co‐occurring mood and substance use disorders: a new therapeutic target. Am J Psychiatry. 2013;170:23‐30. O'Donnell JM, Shelton RC, Brunton LL, et al. Drug therapy of depression and anxiety disorders(s). In: Goodman & Gilman's the Pharmacological Basis of Therapeutics. 12th ed. Columbus, OH: McGraw‐Hill, Medical Publishing Division; 2011:397–415. Omori IM, Watanabe N, Nakagawa A, et al. Fluvoxamine versus other anti-depressive agents for depression. Cochrane Database Syst Rev. 2010:CD006114. Spear BB, Heath-Chiozzi M, Huff J. Clinical application of pharmacogenetics. Trends Mol Med. 2001;7:201–204. Spigset O, Axelsson S, Norström A, et al. The major fluvoxamine metabolite in urine is formed by CYP2D6. Eur J Clin Pharmacol. 2001;57:653–658. Hicks JK, Bishop JR, Sangkuhl K, et al. Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther. 2015;98:127–134. Miura M, Ohkubo T. Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine. Xenobiotica. 2007;37:169–179. Sistonen J, Sajantila A, Lao O, et al. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 2007;17:93–101. Sychev DA, Burashnikova IS, Kazakov RE. 1846G>A polymorphism of CYP2D6 gene and extrapyramidal side effects during antipsychotic therapy among Russians and Tatars: a pilot study. Drug Metab Pers Ther. 2016;31:205–212. Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:23–37. Neafsey P, Ginsberg G, Hattis D, et al. Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): population distribution of CYP2D6 activity. J Toxicol Environ Health B Crit Rev. 2009;12:334–361. Zhou SF. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48:689–723. Bertilsson L, Dahl ML, Dalen P, et al. Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs. Br J Clin Pharmacol. 2002;53:111–122. Griese EU, Zanger UM, Brudermanns U, et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics. 1998;8:15–26. Sachse C, Brockmöller J, Bauer S, et al. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997;60:284–295. Zeng L, Chen Y, Wang Y, et al. MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation. Biochem Pharmacol. 2017;140:139–149. Jiang XL, Shen HW, Yu AM. Pinoline may be used as a probe for CYP2D6 activity. Drug Metab Dispos. 2009;37:443–446. Sychev DA, Zastrozhin MS, Miroshnichenko II, et al. Genotyping and phenotyping of CYP2D6 and CYP3A isoenzymes in patients with alcohol use disorder: correlation with haloperidol plasma concentration. Drug Metab Pers Ther. 2017;32:129–136. Zastrozhin MS, Skryabin VY, Smirnov VV, et al. Effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders and comorbid alcohol use disorder. Can J Physiol Pharmacol. 2019;97:781–785. Flannery BA, Volpicelli JR, Pettinati HM. Psychometric properties of the penn alcohol craving scale. Alcohol Clin Exp Res. 1999;23:1289–1295. Heller GZ, Manuguerra M, Chow R. How to analyze the visual Analogue scale: myths, truths and clinical relevance. Scand J Pain. 2016;13:67–75. Busner J, Targum SD. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont). 2007;4:28–37. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–370. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62. Lingjaerde O, Ahlfors UG, Bech P, et al. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl. 1987;334:1–100. Zastrozhin MS, Grishina EA, Denisenko NP, et al. Effects of CYP2D6 genetic polymorphisms on the efficacy and safety of fluvoxamine in patients with depressive disorder and comorbid alcohol use disorder. Pharmgenomics Pers Med. 2018;11:113–119. Zastrozhin MS, Sorokin AS, Agibalova TV, et al. Using a personalized clinical decision support system for bromdihydrochlorphenylbenzodiazepine dosing in patients with anxiety disorders based on the pharmacogenomic markers. Hum Psychopharmacol. 2018;33:e2677. |
المشرفين على المادة: | 0 (MIRN370 microRNA, human) 0 (MicroRNAs) EC 1.14.14.1 (Cytochrome P-450 CYP2D6) O4L1XPO44W (Fluvoxamine) |
تواريخ الأحداث: | Date Created: 20210612 Date Completed: 20220110 Latest Revision: 20220429 |
رمز التحديث: | 20221213 |
DOI: | 10.1097/MJT.0000000000001388 |
PMID: | 34117140 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1536-3686 |
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DOI: | 10.1097/MJT.0000000000001388 |