دورية أكاديمية
أعرض في EDS

Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma.

التفاصيل البيبلوغرافية
العنوان: Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma.
المؤلفون: Lake CM; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Bondoc AJ; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Dasgupta R; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Jenkins TM; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Towbin AJ; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Smith EA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Alonso MH; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Geller JI; Division of Pediatric Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Tiao GM; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
المصدر: Cancer medicine [Cancer Med] 2021 Jul; Vol. 10 (13), pp. 4322-4343. Date of Electronic Publication: 2021 Jun 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-
مواضيع طبية MeSH: Coloring Agents* , Indocyanine Green* , Margins of Excision* , Metastasectomy*, Hepatoblastoma/*surgery , Liver Neoplasms/*surgery , Thoracic Neoplasms/*surgery, Child ; Child, Preschool ; Female ; Hepatoblastoma/diagnostic imaging ; Hepatoblastoma/pathology ; Hepatoblastoma/secondary ; Humans ; Infant ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Male ; Retrospective Studies ; Sensitivity and Specificity ; Thoracic Neoplasms/diagnostic imaging ; Thoracic Neoplasms/secondary
مستخلص: Background: Hepatoblastoma is the most common primary pediatric liver malignancy. Indocyanine green (ICG) has been described as an adjunct to resection in small series. Its utility remains undefined in larger cohorts.
Methods: Records for 29 patients diagnosed with hepatoblastoma who received ICG prior to surgical resection from 2017 to 2020 at a single institution were retrospectively reviewed. The primary outcome was correlation between intraoperative ICG-avidity and histologic presence of hepatoblastoma. A secondary outcome included the histologic margin designation for resected liver specimens.
Results: ICG sensitivity was 91% for 120 resected thoracic specimens from 21 patients. Specificity was 57%. In 10% of operations, HB-positive specimens were resected solely on ICG-avidity. In an additional 40% of cases, ICG assisted in localizing a preoperatively diagnosed lesion. ICG sensitivity during thoracotomy and thoracoscopic surgery was 95 and 74%, respectively; primary and relapsed disease demonstrated sensitivity of 94 and 73%, respectively. Sensitivity was 92% for 25 resected liver specimens from nine patients with all parenchymal margins grossly negative for disease. Four multifocal lesions were identified with two resected solely by ICG-avidity.
Conclusions: ICG is a sensitive adjunct for identifying local and metastatic hepatoblastoma, including lesions not visualized on preoperative imaging, and delineating margins during liver resection. False positives limit specificity; however, there were no adverse outcomes from additional resections. We noted that thoracoscopic surgery can be completed safely in patients with less significant disease burden, and conversion to thoracotomy, if necessary, is straightforward.
(© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: hepatectomy; hepatoblastoma; indocyanine green; metastasectomy; pediatric surgery; thoracoscopy; thoracotomy
المشرفين على المادة: 0 (Coloring Agents)
IX6J1063HV (Indocyanine Green)
تواريخ الأحداث: Date Created: 20210612 Date Completed: 20211231 Latest Revision: 20211231
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8267136
DOI: 10.1002/cam4.3982
PMID: 34117727
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-7634
DOI:10.1002/cam4.3982