دورية أكاديمية
أعرض في EDS

Distinct contribution of hyperbaric oxygen therapy to human neutrophil function and antibiotic efficacy against Staphylococcus aureus.

التفاصيل البيبلوغرافية
العنوان: Distinct contribution of hyperbaric oxygen therapy to human neutrophil function and antibiotic efficacy against Staphylococcus aureus.
المؤلفون: Schwartz FA; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark., Lerche CJ; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark., Christophersen L; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark., Jensen PØ; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.; Department of Microbiology and Immunology & LEO Foundation Skin Immunology Research Center, Copenhagen University, Copenhagen, Denmark.; Center for Rheumatology and Spine Diseases, Institute for Inflammation Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark., Laulund AS; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark., Woetmann A; Department of Microbiology and Immunology & LEO Foundation Skin Immunology Research Center, Copenhagen University, Copenhagen, Denmark., Høiby N; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.; Department of Microbiology and Immunology & LEO Foundation Skin Immunology Research Center, Copenhagen University, Copenhagen, Denmark., Moser C; Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.
المصدر: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2021 Sep; Vol. 129 (9), pp. 566-573. Date of Electronic Publication: 2021 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8803400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0463 (Electronic) Linking ISSN: 09034641 NLM ISO Abbreviation: APMIS Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Munksgaard
Original Publication: Copenhagen : Munksgaard, c1988-
مواضيع طبية MeSH: Hyperbaric Oxygenation*, Neutrophils/*immunology , Staphylococcus aureus/*drug effects , Staphylococcus aureus/*immunology, Anti-Bacterial Agents/administration & dosage ; Ciprofloxacin/administration & dosage ; Combined Modality Therapy ; Humans ; Hyperoxia/immunology ; In Vitro Techniques ; Microbial Sensitivity Tests ; Neutrophils/metabolism ; Penicillins/administration & dosage ; Reactive Oxygen Species/metabolism ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/therapy ; Tobramycin/administration & dosage
مستخلص: Staphylococcus aureus (SA) causes superficial and severe endovascular infections. The present in vitro study investigates the anti-SA mechanisms of hyperbaric oxygen therapy (HBOT) on direct bacterial killing, antibiotic potentiation, and polymorphonuclear leukocyte (PMN) enhancement. SA was exposed to isolated human PMNs, tobramycin, ciprofloxacin, or benzylpenicillin. HBOT was used as one 90-min session. Bacterial survival was evaluated after 4 h by quantitative bacteriology. PMN functionality as reactive oxygen species (ROS) production was measured by means of dihydrorhodamine 123 analysis. We showed that HBOT exhibits significant direct anti-SA effects. HBOT increased the anti-SA effects of PMNs by 18% after PMA stimulation (p = 0.0004) and by 15% in response to SA (p = 0.36). HBOT showed an additive effect as growth reductions of 26% to sub-MICs of tobramycin (p = 0.0057), 44% to sub-MICs of ciprofloxacin (p = 0.0001), and 26% to sub-MICs of penicillin (p = 0.038). The present in vitro study provides evidence that HBOT has differential mechanisms mediating its anti-SA effects. Our observation supports the clinical possibility for adjunctive HBOT to augment the host immune response and optimize the efficacy of antibiotic treatments.
(© 2021 Scandinavian Societies for Medical Microbiology and Pathology.)
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معلومات مُعتمدة: NNF17OC0025074 Novo Nordisk Fonden; 19-L-0283 A.P. Møller Fonden
فهرسة مساهمة: Keywords: Infection; host response; hyperbaric oxygen therapy; neutrophils; oxidative stress
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Penicillins)
0 (Reactive Oxygen Species)
5E8K9I0O4U (Ciprofloxacin)
VZ8RRZ51VK (Tobramycin)
تواريخ الأحداث: Date Created: 20210613 Date Completed: 20210812 Latest Revision: 20210812
رمز التحديث: 20221213
DOI: 10.1111/apm.13164
PMID: 34120378
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0463
DOI:10.1111/apm.13164