دورية أكاديمية
Characteristics of circular RNAs expression of peripheral blood mononuclear cells in humans with coronary artery disease.
| العنوان: | Characteristics of circular RNAs expression of peripheral blood mononuclear cells in humans with coronary artery disease. |
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| المؤلفون: | Ji WF; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Cardiovascular Medicine, Nanjing Qixia District Hospital, Nanjing, Jiangsu, China., Chen JX; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., He S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Zhou YQ; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Hua L; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Hou C; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Zhang S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Gan XK; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Wang YJ; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Zhou HX; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Li Q; Department of Cardiovascular Medicine, Nanjing Qixia District Hospital, Nanjing, Jiangsu, China., Jia EZ; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. |
| المصدر: | Physiological genomics [Physiol Genomics] 2021 Aug 01; Vol. 53 (8), pp. 349-357. Date of Electronic Publication: 2021 Jun 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 9815683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-2267 (Electronic) Linking ISSN: 10948341 NLM ISO Abbreviation: Physiol Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Physiological Society, c1999- |
| مواضيع طبية MeSH: | Coronary Artery Disease/*blood , Coronary Artery Disease/*genetics , Leukocytes, Mononuclear/*physiology , RNA, Circular/*blood, Aged ; Case-Control Studies ; Female ; Gene Expression ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; RNA, Circular/genetics ; RNA, Messenger/genetics ; Sequence Analysis, RNA |
| مستخلص: | Circular RNAs (circRNAs) function as promising biomarkers and therapeutic targets for coronary artery disease due to their high stability, covalently closed structure, and potential gene regulation. We aimed to identify the expression profile and role of circular RNAs (circRNAs) in coronary artery disease (CAD). We performed RNA sequence analysis of circRNAs in peripheral blood mononuclear cells of five patients with CAD and five controls. Bioinformatics analyses were adopted to explore biological functions of differentially expressed circRNAs. The miRanda and TargetScan tools were used to predict the microRNA (miRNA)-targeting interactions and to construct a triple network of differentially expressed gene-circRNA-miRNA-mRNA. In total, 13,160 downregulated and 12,905 upregulated circRNAs were identified in CAD. A gene ontology annotation analysis showed that genes in the network were involved in organelle organization, cell cycle, mitotic cycle, and cellular metabolic process. Parental genes of the 10 dysregulated circRNAs were involved in metabolism and protein modification, and these circRNAs might regulate gene expression associated with CAD via miRNA sponges. As potential competing endogenous RNAs (ceRNAs), dysregulated circRNAs may be involved in the pathogenesis of CAD, which provides new insights into the diagnosis and prognosis of coronary artery disease. |
| فهرسة مساهمة: | Keywords: RNA sequencing; atherosclerosis; circular RNA; coronary artery disease; peripheral blood mononuclear cells |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (RNA, Circular) 0 (RNA, Messenger) |
| تواريخ الأحداث: | Date Created: 20210614 Date Completed: 20220207 Latest Revision: 20220207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1152/physiolgenomics.00020.2021 |
| PMID: | 34121455 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1531-2267 |
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| DOI: | 10.1152/physiolgenomics.00020.2021 |