دورية أكاديمية
Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of Actions.
| العنوان: | Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of Actions. |
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| المؤلفون: | Alam S; Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh., Sarker MMR; Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.; Pharmacology and Toxicology Research Division, Health Med Science Research Limited, Dhaka, Bangladesh., Afrin S; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh., Richi FT; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh., Zhao C; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China., Zhou JR; Nutrition/Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Mohamed IN; Pharmacology Department, Medical Faculty, Universiti Kebangsaan Malaysia (The National University of Malaysia), Kuala Lumpur, Malaysia. |
| المصدر: | Frontiers in pharmacology [Front Pharmacol] 2021 May 28; Vol. 12, pp. 671498. Date of Electronic Publication: 2021 May 28 (Print Publication: 2021). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Media] |
| مستخلص: | SARS-CoV-2 is the latest worldwide pandemic declared by the World Health Organization and there is no established anti-COVID-19 drug to combat this notorious situation except some recently approved vaccines. By affecting the global public health sector, this viral infection has created a disastrous situation associated with high morbidity and mortality rates along with remarkable cases of hospitalization because of its tendency to be high infective. These challenges forced researchers and leading pharmaceutical companies to find and develop cures for this novel strain of coronavirus. Besides, plants have a proven history of being notable wellsprings of potential drugs, including antiviral, antibacterial, and anticancer therapies. As a continuation of this approach, plant-based preparations and bioactive metabolites along with a notable number of traditional medicines, bioactive phytochemicals, traditional Chinese medicines, nutraceuticals, Ayurvedic preparations, and other plant-based products are being explored as possible therapeutics against COVID-19. Moreover, the unavailability of effective medicines against COVID-19 has driven researchers and members of the pharmaceutical, herbal, and related industries to conduct extensive investigations of plant-based products, especially those that have already shown antiviral properties. Even the recent invention of several vaccines has not eliminated doubts about safety and efficacy. As a consequence, many limited, unregulated clinical trials involving conventional mono- and poly-herbal therapies are being conducted in various areas of the world. Of the many clinical trials to establish such agents as credentialed sources of anti-COVID-19 medications, only a few have reached the landmark of completion. In this review, we have highlighted and focused on plant-based anti-COVID-19 clinical trials found in several scientific and authenticated databases. The aim is to allow researchers and innovators to identify promising and prospective anti-COVID-19 agents in clinical trials (either completed or recruiting) to establish them as novel therapies to address this unwanted pandemic. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Alam, Sarker, Afrin, Richi, Zhao, Zhou and Mohamed.) |
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| فهرسة مساهمة: | Keywords: Ayurved medicine; anti-COVID-19; anti-infective; antiviral; bioactive metabolites; phytochemicals; phytomedicine; traditional Chinese medicine |
| تواريخ الأحداث: | Date Created: 20210614 Latest Revision: 20231111 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC8194295 |
| DOI: | 10.3389/fphar.2021.671498 |
| PMID: | 34122096 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1663-9812 |
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| DOI: | 10.3389/fphar.2021.671498 |