دورية أكاديمية
Phytoprostane and phenolic compounds from Chromolaena palmaris .
| العنوان: | Phytoprostane and phenolic compounds from Chromolaena palmaris . |
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| المؤلفون: | Souza MRP; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Ramos AVG; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Oliveira JAM; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Cabral MRP; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Sampiron EG; Departamento de Análises Clínicas e Biomedicina, UEM, Maringá, Paraná, Brazil., Scodro RBL; Departamento de Análises Clínicas e Biomedicina, UEM, Maringá, Paraná, Brazil., Foglio MA; Faculdade de Ciências Farmacêuticas, Universidade de Campinas, Campinas, São Paulo, Brazil., Ruiz ALTG; Faculdade de Ciências Farmacêuticas, Universidade de Campinas, Campinas, São Paulo, Brazil., Carmo MRBD; Departamento de Biologia Geral, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brazil., Sarragiotto MH; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Baldoqui DC; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. |
| المصدر: | Natural product research [Nat Prod Res] 2022 Oct; Vol. 36 (20), pp. 5376-5379. Date of Electronic Publication: 2021 Jun 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Anti-Infective Agents*/pharmacology , Chromolaena*/chemistry , Tuberculosis*, Flavonoids/chemistry ; Glucosides ; Humans ; Methylene Chloride ; Phenols/pharmacology ; Phytochemicals ; Plant Extracts/chemistry ; Plant Extracts/pharmacology |
| مستخلص: | The chemical investigation of Chromolaena palmaris (Sch.Bip . ex Baker) R.M. King & H. Rob. expands the phytochemical composition knowledge of Chromolaena genus, since this is the first chemical investigation of this species. Twenty-five compounds were identified, including a phytoprostane, 17 flavonoids, 6 phenolic acids, and a caffeoyl-glucoside derivative obtained by classical chromatography and UHPLC-HRMS/MS analysis. Moreover, anti- Mycobacterium tuberculosis and antiproliferative activities of C. palmaris were evaluated. Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 μg mL -1 . Furthermore, compounds 1 and 2 exhibited antimicrobial activity against Mycobacterium tuberculosis with MIC of 62.5 and 15.6 μg mL -1 , respectively. |
| فهرسة مساهمة: | Keywords: Asteraceae; Chromolaena palmaris; antiproliferative activity; antitubercular activity; flavonoids; phytoprostanes |
| المشرفين على المادة: | 0 (Anti-Infective Agents) 0 (Flavonoids) 0 (Glucosides) 0 (Phenols) 0 (Phytochemicals) 0 (Plant Extracts) 588X2YUY0A (Methylene Chloride) |
| تواريخ الأحداث: | Date Created: 20210614 Date Completed: 20221017 Latest Revision: 20221017 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14786419.2021.1937155 |
| PMID: | 34124970 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2021.1937155 |