دورية أكاديمية
Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy.
| العنوان: | Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy. |
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| المؤلفون: | Guo W; Department of Chemistry and Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 000000, Hong Kong., Zhang J; Department of Chemistry and Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 000000, Hong Kong., Sun Z; Department of Chemistry and Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 000000, Hong Kong., Orem WH; U.S. Geological Survey, Reston, Virginia 20192, United States., Tatu CA; Department of Immunology, University of Medicine and Pharmacy ″Victor Babes″ Timisoara, Pta. E. Murgu No.2, 300041 Timisoara, Romania., Radulović NS; Faculty of Sciences and Mathematics, University of Niš, 18000 Niš, Serbia., Milovanović D; Universitet u Nišu, 18000 Niš, Serbia., Pavlović NM; Universitet u Nišu, 18000 Niš, Serbia., Chan W; Department of Chemistry and Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 000000, Hong Kong. |
| المصدر: | Environmental science & technology [Environ Sci Technol] 2021 Jul 06; Vol. 55 (13), pp. 9024-9032. Date of Electronic Publication: 2021 Jun 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington DC : American Chemical Society Original Publication: Easton, Pa. : American Chemical Society, c1967- |
| مواضيع طبية MeSH: | Aristolochic Acids*/analysis , Aristolochic Acids*/toxicity , Balkan Nephropathy*/chemically induced , Balkan Nephropathy*/epidemiology , Polycyclic Aromatic Hydrocarbons*/toxicity, Balkan Peninsula ; DNA Adducts ; Esters ; Humans ; Phthalic Acids ; Soil |
| مستخلص: | Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial nephropathy affecting residents of rural farming areas in many Balkan countries. Although it is generally believed that BEN is an environmental disease caused by multiple geochemical factors with much attention on aristolochic acids (AAs), its etiology remains controversial. In this study, we tested the hypothesis that environmental contamination and subsequent food contamination by polycyclic aromatic hydrocarbons (PAHs) and phthalate esters are AA toxicity factors and important to BEN development. We identified significantly higher concentrations of phenanthrene, anthracene, diethyl phthalate (DEP), dibutyl phthalate (DBP), and benzyl butyl phthalate (BBP) in both maize and wheat grain samples collected from endemic villages than from nonendemic villages. Other PAHs and phthalate esters were also detected at higher concentrations in the soil samples from endemic villages. Subsequent genotoxicity testing of cultured human kidney cells showed an alarming phenomenon that phenanthrene, DEP, BBP, and DBP can interact synergistically with AAs to form elevated levels of AA-DNA adducts, which are associated with both the nephrotoxicity and carcinogenicity of AAs, further increasing their disease risks. This study provides direct evidence that prolonged coexposure to these environmental contaminants via dietary intake may lead to greater toxicity and accelerated development of BEN. |
| فهرسة مساهمة: | Keywords: Balkan endemic nephropathy; DNA adducts; aristolochic acids; phthalate esters; polycyclic aromatic hydrocarbons; synergistic interactions |
| المشرفين على المادة: | 0 (Aristolochic Acids) 0 (DNA Adducts) 0 (Esters) 0 (Phthalic Acids) 0 (Polycyclic Aromatic Hydrocarbons) 0 (Soil) 6O7F7IX66E (phthalic acid) 94218WFP5T (aristolochic acid I) |
| تواريخ الأحداث: | Date Created: 20210614 Date Completed: 20210712 Latest Revision: 20210712 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/acs.est.1c00648 |
| PMID: | 34125507 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5851 |
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| DOI: | 10.1021/acs.est.1c00648 |