دورية أكاديمية
Ethno medical knowledge and traditional use of Aristolochia bracteolata Lam. for malaria among local communities in Jubek State of South Sudan: A cross-sectional survey.
| العنوان: | Ethno medical knowledge and traditional use of Aristolochia bracteolata Lam. for malaria among local communities in Jubek State of South Sudan: A cross-sectional survey. |
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| المؤلفون: | Mathew LS; Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda. Electronic address: lmathew@std.must.ac.ug., Peter EL; Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda. Electronic address: epeterlyimo@gmail.com., Weisheit A; Pharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, Mbarara Uganda. Electronic address: aweisheit@must.ac.ug., Tolo CU; Pharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, Mbarara Uganda. Electronic address: tolocas@must.ac.ug., Deng AL; College of Natural Resources and Environmental Studies, Juba University, South Sudan. Electronic address: agerkuei@gmail.com., Ogwang PE; Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; Pharmbiotechnology and Traditional Medicine Center of Excellence, Mbarara University of Science and Technology, Mbarara Uganda. Electronic address: pogwang@must.ac.ug. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2021 Oct 28; Vol. 279, pp. 114314. Date of Electronic Publication: 2021 Jun 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Antimalarials/*isolation & purification , Aristolochia/*chemistry , Malaria/*drug therapy , Plant Preparations/*therapeutic use, Adolescent ; Adult ; Antimalarials/adverse effects ; Antimalarials/chemistry ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Medicine, African Traditional/methods ; Middle Aged ; Phytotherapy/methods ; Plant Preparations/adverse effects ; Plant Preparations/chemistry ; South Sudan ; Surveys and Questionnaires ; Young Adult |
| مستخلص: | Ethnopharmacological Relevance: The recognized challenges to access conventional antimalarial medicines could have contributed to the extensive use of Aristolochia bracteolata Lam. (Aristolochiaceae)to manage malaria in South Sudan traditionally. However, the use and acquired experiences are notwell documented. Aim of the Study: This study aimed to document the traditional use of A. bracteolata for malaria treatment and experiences among the local communities in Jubek State of South Sudan. Methods: We performed a cross-sectional study in four counties in Jubek State and interviewed 396 community members, including traditional healers, using a semi-structured questionnaire. Four focused group discussions (FGDs) were also conducted using the interviewer guide. The inclusion criteria were; adults 18 years and older, men andwomen participants, at least one year residing in the study area before the study, and those with a history of medicinal plant use. Data were summarized and presented as proportions. Qualitative data were analyzed using a thematic content approach. The major themes that emerged were discussed. We applied the Pearson Chi-Square test at α = 0.05 to test the study's significant differences in responses. The statistical package for social sciences version 21 software was used for data analysis. Results: Women accounted for 208 (52.5%) of participants, with the majority 321 (81.1%) were between 18 and 45 years. Interestingly, most 312 (78.8%) had formal education. Moreover, about 208 (52.5%) participants collect the plant in their vicinity, where leaves were the most commonly used part 277 (46.4%), followed by the roots, seeds, and stems at 245(41.0%), 71 (11.9%), and 4 (0.7%), respectively. Furthermore, about 63 (15.9%) of the participants experienced side effects, including early abortions, heartburns, sweating, and stomach discomforts. Conversely, a total of 387 (96.0%) reported getting cured of malaria. Generally, the quantity of medicine taken per day differs concerning parts of the plant, with leaves ranging from 1 to 10 pieces, roots at 0.4-1 g, and seeds at 0.1-0.5 g. The locals used these plant parts to prepare infusion and decoction traditional dosage forms for oral use. Conclusion: The documented medicinal plant's therapeutic uses provided critical information on the traditional use of A. bracteolata by the community in Jubek state of South Sudan to treat malaria. Although most users reported getting cured of malaria, a notable proportion of them experienced side effects, including early-stage abortion and stomach discomforts. Thus, the use of A. bracteolata preparations, particularly in pregnant women, should be avoided. Finally, further studies are needed to devise a strategy to neutralize the toxic compounds and create community awareness on best practices to minimize side effects. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Adverse effect; Aristolochia bracteolata; Herbal medicine; Malaria; Safety; South Sudan |
| المشرفين على المادة: | 0 (Antimalarials) 0 (Plant Preparations) |
| تواريخ الأحداث: | Date Created: 20210614 Date Completed: 20220111 Latest Revision: 20220111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jep.2021.114314 |
| PMID: | 34126212 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2021.114314 |