دورية أكاديمية
The role of incretins and incretin-based drugs in autoimmune diseases.
| العنوان: | The role of incretins and incretin-based drugs in autoimmune diseases. |
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| المؤلفون: | Radbakhsh S; Department of Medical Biotechnology and Nanotechnology, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran., Atkin SL; Weill Cornell Medicine Qatar, Doha, Qatar., Simental-Mendia LE; Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico., Sahebkar A; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Medicine, The University of Western Australia, Perth, Australia; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir. |
| المصدر: | International immunopharmacology [Int Immunopharmacol] 2021 Sep; Vol. 98, pp. 107845. Date of Electronic Publication: 2021 Jun 11. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Autoimmune Diseases/*metabolism , B-Lymphocyte Subsets/*immunology , Incretins/*metabolism , T-Lymphocytes/*immunology, Animals ; Dipeptidyl-Peptidase IV Inhibitors ; Humans ; Immune System |
| مستخلص: | Incretin hormones, including glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP), are gastrointestinal peptides secreted from enteroendocrine cells. These hormones play significant roles in many physiological processes via binding to G-protein coupled receptors (GPCRs) on different organs and tissues; one of them is the immunomodulatory effect on the immune system and its molecular components such as cytokines and chemokines. Anti-inflammatory effects of incretins and dependent molecules involving long-acting analogs and DPP4 inhibitors through regulation of T and B cell activation may attenuate autoimmune diseases caused by immune system disorders in mistakenly recognizing self as the foreign agent. In this review, we investigate incretin effects on the immune system response and the potential benefits of incretin-based therapy for treating autoimmune diseases. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autoimmune diseases; DPP4 inhibitor; GIP; GLP1; Incretin receptor agonist; Incretin-based therapy |
| المشرفين على المادة: | 0 (Dipeptidyl-Peptidase IV Inhibitors) 0 (Incretins) |
| تواريخ الأحداث: | Date Created: 20210614 Date Completed: 20220201 Latest Revision: 20220201 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.intimp.2021.107845 |
| PMID: | 34126341 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-1705 |
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| DOI: | 10.1016/j.intimp.2021.107845 |