دورية أكاديمية

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review.

التفاصيل البيبلوغرافية
العنوان: Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review.
المؤلفون: Mulder MLM; Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, The Netherlands. m.mulder@maartenskliniek.nl.; Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands. m.mulder@maartenskliniek.nl., van Hal TW; Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, The Netherlands.; Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands., Wenink MH; Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, The Netherlands., Koenen HJPM; Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., van den Hoogen FHJ; Radboud University, Nijmegen, The Netherlands., de Jong EMGJ; Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud University, Nijmegen, The Netherlands.; Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands., van den Reek JMPA; Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands., Vriezekolk JE; Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, The Netherlands.
المصدر: Arthritis research & therapy [Arthritis Res Ther] 2021 Jun 14; Vol. 23 (1), pp. 168. Date of Electronic Publication: 2021 Jun 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review; Systematic Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2003-
مواضيع طبية MeSH: Arthritis, Psoriatic* , Psoriasis*, Early Diagnosis ; Genetic Markers ; Humans ; Laboratories
مستخلص: Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conducted a systematic search of five bibliographic databases, up to May 2020. We searched for studies assessing markers (clinical, laboratory, genetic) associated with the development or presence of PsA in Pso patients. Study selection and quality assessment of the included studies was performed, followed by a qualitative best evidence synthesis to determine the level of evidence for a marker and its association with concomitant/developing PsA in Pso. Overall, 259 possible markers were identified in 119 studies that met the inclusion criteria. Laboratory markers related to inflammation and bone metabolism reached a strong level of evidence for the association (not prediction) of PsA in Pso. Only CXCL10 showed strong evidence for a positive predictive value for PsA in Pso. The importance of timely detecting PsA in a Pso population, and finding more (bio)markers contributing to early detection, remains high.
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فهرسة مساهمة: Keywords: (Bio)marker; Clinical; Genetic; Laboratory; Psoriasis; Psoriatic arthritis; Screening; Systematic review
المشرفين على المادة: 0 (Genetic Markers)
تواريخ الأحداث: Date Created: 20210615 Date Completed: 20210629 Latest Revision: 20210629
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8201808
DOI: 10.1186/s13075-021-02545-4
PMID: 34127053
قاعدة البيانات: MEDLINE
الوصف
تدمد:1478-6362
DOI:10.1186/s13075-021-02545-4