دورية أكاديمية
أعرض في EDS

Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury.

التفاصيل البيبلوغرافية
العنوان: Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury.
المؤلفون: Ustaoglu SG; Department of Medical Biochemistry, Faculty of Medicine, Altinbas University, Bakirkoy, Istanbul, Turkey. sebnem.garip@altinbas.edu.tr., Ali MHM; Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), P.O. Box 34110, Doha, Qatar. moaam@yahoo.com., Rakib F; Department of Chemistry and Earth Sciences, Qatar University, Doha, Qatar., Blezer ELA; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands., Van Heijningen CL; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands., Dijkhuizen RM; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands., Severcan F; Department of Biophysics, Faculty of Medicine, Altinbas University, Bakirkoy, Istanbul, Turkey.; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.
المصدر: Scientific reports [Sci Rep] 2021 Jun 14; Vol. 11 (1), pp. 12468. Date of Electronic Publication: 2021 Jun 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Brain Injuries, Traumatic/*diagnosis , Hippocampus/*pathology, Animals ; Brain Injuries, Traumatic/pathology ; Disease Models, Animal ; Hippocampus/cytology ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism ; Humans ; Injury Severity Score ; Lipid Metabolism ; Lipids/analysis ; Male ; Membrane Fluidity ; Protein Structure, Secondary ; Rats ; Spectroscopy, Fourier Transform Infrared ; Time Factors
مستخلص: Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI is crucial to understand secondary and long-term effects after traumatic brain injury, and to develop and apply the correct therapies. In the current study, the molecular effects of TBI were investigated in rat brain at 24 h and 1 month after the injury to determine acute and chronic effects, respectively by Fourier transform infrared imaging. This study reports the time-dependent contextual and structural effects of TBI on hippocampal brain tissue. A mild form of TBI was induced in 11-week old male Sprague Dawley rats by weight drop. Band area and intensity ratios, band frequency and bandwidth values of specific spectral bands showed that TBI causes significant structural and contextual global changes including decrease in carbonyl content, unsaturated lipid content, lipid acyl chain length, membrane lipid order, total protein content, lipid/protein ratio, besides increase in membrane fluidity with an altered protein secondary structure and metabolic activity in hippocampus 24 h after injury. However, improvement and/or recovery effects in these parameters were observed at one month after TBI.
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المشرفين على المادة: 0 (Lipids)
تواريخ الأحداث: Date Created: 20210615 Date Completed: 20211101 Latest Revision: 20211101
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8203626
DOI: 10.1038/s41598-021-92015-3
PMID: 34127773
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-92015-3