دورية أكاديمية
أعرض في EDS

Genome analysis of Candida subhashii reveals its hybrid nature and dual mitochondrial genome conformations.

التفاصيل البيبلوغرافية
العنوان: Genome analysis of Candida subhashii reveals its hybrid nature and dual mitochondrial genome conformations.
المؤلفون: Mixão V; Life Sciences Department, Barcelona Supercomputing Center (BSC), Jordi Girona, 29, 08034 Barcelona, Spain.; Mechanisms of Disease Department, Institute for Research in Biomedicine (IRB), Barcelona, Spain., Hegedűsová E; Faculty of Natural Sciences, Department of Biochemistry, Comenius University in Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovak Republic., Saus E; Life Sciences Department, Barcelona Supercomputing Center (BSC), Jordi Girona, 29, 08034 Barcelona, Spain.; Mechanisms of Disease Department, Institute for Research in Biomedicine (IRB), Barcelona, Spain., Pryszcz LP; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Cillingová A; Faculty of Natural Sciences, Department of Biochemistry, Comenius University in Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovak Republic., Nosek J; Faculty of Natural Sciences, Department of Biochemistry, Comenius University in Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovak Republic., Gabaldón T; Life Sciences Department, Barcelona Supercomputing Center (BSC), Jordi Girona, 29, 08034 Barcelona, Spain.; Mechanisms of Disease Department, Institute for Research in Biomedicine (IRB), Barcelona, Spain.; ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain.
المصدر: DNA research : an international journal for rapid publication of reports on genes and genomes [DNA Res] 2021 Jun 25; Vol. 28 (3).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9423827 Publication Model: Print Cited Medium: Internet ISSN: 1756-1663 (Electronic) Linking ISSN: 13402838 NLM ISO Abbreviation: DNA Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : Oxford : Oxford University Press
Original Publication: Tokyo, Japan : Kazusa DNA Research Institute ; Universal Academy Press [1994-
مواضيع طبية MeSH: Genome, Fungal* , Genome, Mitochondrial* , Metabolic Networks and Pathways*, Candida/*genetics , Cell Nucleus/*genetics , Phenols/*metabolism, Candida/metabolism ; Whole Genome Sequencing
مستخلص: Candida subhashii belongs to the CUG-Ser clade, a group of phylogenetically closely related yeast species that includes some human opportunistic pathogens, such as Candida albicans. Despite being present in the environment, C. subhashii was initially described as the causative agent of a case of peritonitis. Considering the relevance of whole-genome sequencing and analysis for our understanding of genome evolution and pathogenicity, we sequenced, assembled and annotated the genome of C. subhashii type strain. Our results show that C. subhashii presents a highly heterozygous genome and other signatures that point to a hybrid ancestry. The presence of functional pathways for assimilation of hydroxyaromatic compounds goes in line with the affiliation of this yeast with soil microbial communities involved in lignin decomposition. Furthermore, we observed that different clones of this strain may present circular or linear mitochondrial DNA. Re-sequencing and comparison of strains with differential mitochondrial genome topology revealed five candidate genes potentially associated with this conformational change: MSK1, SSZ1, ALG5, MRPL9 and OYE32.
(© The Author(s) 2021. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.)
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معلومات مُعتمدة: European Union's Horizon 2020 Research and Innovation
فهرسة مساهمة: Keywords: Candida subhashii; genome assembly; hybrid; metabolism of hydroxyaromatic compounds; mitochondria
المشرفين على المادة: 0 (Phenols)
SCR Organism: Candida subhashii
تواريخ الأحداث: Date Created: 20210615 Date Completed: 20210817 Latest Revision: 20210817
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8311171
DOI: 10.1093/dnares/dsab006
PMID: 34129020
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-1663
DOI:10.1093/dnares/dsab006