دورية أكاديمية
أعرض في EDS

Community Violence Exposure is Associated with Hippocampus-Insula Resting State Functional Connectivity in Urban Youth.

التفاصيل البيبلوغرافية
العنوان: Community Violence Exposure is Associated with Hippocampus-Insula Resting State Functional Connectivity in Urban Youth.
المؤلفون: Reda MH; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States. Electronic address: mhreda@wayne.edu., Marusak HA; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States., Ely TD; Department of Psychiatry and Behavioral Neurosciences, Emory University School of Medicine, Atlanta, GA, United States., van Rooij SJH; Department of Psychiatry and Behavioral Neurosciences, Emory University School of Medicine, Atlanta, GA, United States., Stenson AF; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States., Stevens JS; Department of Psychiatry and Behavioral Neurosciences, Emory University School of Medicine, Atlanta, GA, United States., France JM; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States., Tottenham N; Department of Psychology, Columbia University, New York, NY, United States., Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States.
المصدر: Neuroscience [Neuroscience] 2021 Aug 01; Vol. 468, pp. 149-157. Date of Electronic Publication: 2021 Jun 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Exposure to Violence*, Adolescent ; Brain ; Cerebral Cortex ; Child ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging
مستخلص: Our previous work has linked childhood violence exposure in Black youth to functional changes in the hippocampus, a brain region sensitive to stress. However, different contexts of violence exposure (e.g., community, home, school) may have differential effects on circuitry. We investigated the unique effect of community violence in predicting resting-state functional connectivity (rsFC) in the hippocampus. Fifty-two (26F) violence-exposed Black youth ages 8-15 performed resting-state functional neuroimaging scans while looking at a fixation cross for seven minutes with eyes open. Seed-based analyses were conducted to examine the association between total violence exposure and rsFC of the hippocampus to the whole brain. Follow-up hierarchical regression analysis were performed to specifically investigate community violence. Violence exposure was associated with higher hippocampus rsFC with a core node of the Default Mode Network (i.e., posterior cingulate cortex) and lower hippocampal rsFC with a core node of the Salience Network (i.e., insula). Community violence uniquely associated with lower hippocampus-insula rsFC, after controlling for home and school violence, sex and age. Age-related decreases in hippocampus-insula rsFC were also present in youth with lower violence exposure, but not in youth with higher violence exposure. This is one of the first studies to investigate the unique impact of community violence, above home and school violence, on threat circuitry. Our data suggest functional alterations in the hippocampus in violence-exposed youth, and that violence in the community may be a more salient form of threat exposure compared to other forms of violence experienced by youth.
(Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: K01 MH119241 United States MH NIMH NIH HHS; K01 MH121653 United States MH NIMH NIH HHS; R01 MH100122 United States MH NIMH NIH HHS; R01 MH111682 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: PTSD; childhood; development; fMRI; trauma; violence
تواريخ الأحداث: Date Created: 20210615 Date Completed: 20210721 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8366937
DOI: 10.1016/j.neuroscience.2021.06.010
PMID: 34129912
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2021.06.010