دورية أكاديمية
Repellent activity of acetylcarvacrol and its effects on salivary gland morphology in unfed Rhipicephalus sanguineus sensu lato ticks (Acari: Ixodidae).
| العنوان: | Repellent activity of acetylcarvacrol and its effects on salivary gland morphology in unfed Rhipicephalus sanguineus sensu lato ticks (Acari: Ixodidae). |
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| المؤلفون: | Konig IFM; Department of Chemistry, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Reis AC; Department of Health Sciences, Federal University of Lavras (UFLA), Av. Dr. Sylvio, Menicucci, 1001 Lavras, MG, Brazil., Gonçalves RRP; Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Oliveira MVS; Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Silva CM; Department of Animal Science, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Melo DS; Department of Biology, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Peconick AP; Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Thomasi SS; Department of Chemistry, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Remedio RN; Department of Health Sciences, Federal University of Lavras (UFLA), Av. Dr. Sylvio, Menicucci, 1001 Lavras, MG, Brazil. Electronic address: rafael.remedio@ufla.br. |
| المصدر: | Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2021 Sep; Vol. 12 (5), pp. 101760. Date of Electronic Publication: 2021 Jun 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101522599 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-9603 (Electronic) Linking ISSN: 1877959X NLM ISO Abbreviation: Ticks Tick Borne Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, 2010- |
| مواضيع طبية MeSH: | Cymenes/*pharmacology , Ixodidae/*drug effects , Salivary Glands/*drug effects, Acaricides/pharmacology ; Animals ; Dogs ; Insect Repellents/pharmacology ; Rhipicephalus sanguineus/drug effects ; Salivary Glands/pathology ; Tick Control/methods ; Tick Infestations/veterinary |
| مستخلص: | Rhipicephalus sanguineus sensu lato (s.l.), commonly known as brown dog tick, is a widely distributed tick species that is substantially important for human and veterinary medicine. Therefore, it is the target of different control methods. Carvacrol and its semisynthetic derivative, acetylcarvacrol, are promising chemical compounds for alternative tick control. Thus, this study aimed to compare the repellent activities of carvacrol and acetylcarvacrol at different concentrations and drying times. Additionally, morphological alterations found in salivary glands were evaluated through histological techniques after exposure to acetylcarvacrol. The impact of the morphological changes on the development and survival of acini/cells in salivary glands was measured by a semiquantitative analysis. The repellent action of both compounds did not differ when evaluated at different concentrations, although acetylcarvacrol increased its effects as the concentration raised. Regarding the different drying times, acetylcarvacrol maintained its effects after 3 hours of exposure, while the efficacy of carvacrol decreased during this time period. Salivary glands of unfed R. sanguineus s.l. females showed dose-dependent alterations in the size and shape of acini as well as cytoplasmic vacuolization. Loss of the acinar cell limit, rupture of secretory granules and nuclear changes in the cells were also observed in the treated groups. Thus, our results demonstrated the potential of acetylcarvacrol to act as repellent against R. sanguineus s.l. Additionally, the morphological alterations found in salivary glands may interfere with the feeding process of ticks, which contributes to mitigate infestation by this species. (Copyright © 2021. Published by Elsevier GmbH.) |
| التعليقات: | Erratum in: Ticks Tick Borne Dis. 2021 Jul 13;:101778. (PMID: 34272197) |
| فهرسة مساهمة: | Keywords: Brown dog tick; Carvacrol acetate; Salivary glands; Tick control; Tick repellent |
| المشرفين على المادة: | 0 (Acaricides) 0 (Cymenes) 0 (Insect Repellents) 9B1J4V995Q (carvacrol) |
| تواريخ الأحداث: | Date Created: 20210615 Date Completed: 20210907 Latest Revision: 20210907 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ttbdis.2021.101760 |
| PMID: | 34130147 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1877-9603 |
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| DOI: | 10.1016/j.ttbdis.2021.101760 |