دورية أكاديمية
أعرض في EDS

The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus.

التفاصيل البيبلوغرافية
العنوان: The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus.
المؤلفون: Trefry JC; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Rossi FD; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Accardi MV; Charles River (formerly Citoxlab North America), Laval, Canada., Dorsey BL; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Sprague TR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Wollen-Roberts SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Shamblin JD; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Kimmel AE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Glass PJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Miller LJ; Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Burke CW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Cardile AP; Division of Medicine, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Smith DR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Bavari S; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Authier S; Charles River (formerly Citoxlab North America), Laval, Canada., Pratt WD; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Pitt ML; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Nasar F; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Jun 17; Vol. 15 (6), pp. e0009424. Date of Electronic Publication: 2021 Jun 17 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Disease Models, Animal* , Electroencephalography* , Encephalitis Virus, Eastern Equine*, Alphavirus Infections/*virology , Monitoring, Physiologic/*instrumentation , Telemetry/*instrumentation, Aerosols ; Alphavirus Infections/pathology ; Animals ; Blood Pressure ; Body Temperature ; Chlorocebus aethiops ; Female ; Heart Rate ; Humans ; Macaca fascicularis ; Male ; Monitoring, Physiologic/methods ; Motor Activity ; Respiratory Physiological Phenomena ; Telemetry/methods ; Vero Cells
مستخلص: Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality rates of 30-90%. Currently, there are no therapeutics or vaccines to treat and/or prevent human infection. One critical impediment in countermeasure development is the lack of insight into clinically relevant parameters in a susceptible animal model. This study examined the disease course of EEEV in a cynomolgus macaque model utilizing advanced telemetry technology to continuously and simultaneously measure temperature, respiration, activity, heart rate, blood pressure, electrocardiogram (ECG), and electroencephalography (EEG) following an aerosol challenge at 7.0 log10 PFU. Following challenge, all parameters were rapidly and substantially altered with peak alterations from baseline ranged as follows: temperature (+3.0-4.2°C), respiration rate (+56-128%), activity (-15-76% daytime and +5-22% nighttime), heart rate (+67-190%), systolic (+44-67%) and diastolic blood pressure (+45-80%). Cardiac abnormalities comprised of alterations in QRS and PR duration, QTc Bazett, T wave morphology, amplitude of the QRS complex, and sinoatrial arrest. An unexpected finding of the study was the first documented evidence of a critical cardiac event as an immediate cause of euthanasia in one NHP. All brain waves were rapidly (~12-24 hpi) and profoundly altered with increases of up to 6,800% and severe diffuse slowing of all waves with decreases of ~99%. Lastly, all NHPs exhibited disruption of the circadian rhythm, sleep, and food/fluid intake. Accordingly, all NHPs met the euthanasia criteria by ~106-140 hpi. This is the first of its kind study utilizing state of the art telemetry to investigate multiple clinical parameters relevant to human EEEV infection in a susceptible cynomolgus macaque model. The study provides critical insights into EEEV pathogenesis and the parameters identified will improve animal model development to facilitate rapid evaluation of vaccines and therapeutics.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Aerosols)
تواريخ الأحداث: Date Created: 20210617 Date Completed: 20211018 Latest Revision: 20211018
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8259972
DOI: 10.1371/journal.pntd.0009424
PMID: 34138849
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0009424