دورية أكاديمية
CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease.
| العنوان: | CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease. |
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| المؤلفون: | Hecker JS; Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany.; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany., Hartmann L; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany., Rivière J; Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Buck MC; Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., van der Garde M; Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany.; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany., Rothenberg-Thurley M; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany., Fischer L; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; Department of Medicine I and., Winter S; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; Department of Medicine I and., Ksienzyk B; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany., Ziemann F; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany., Solovey M; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany., Rauner M; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Center for Healthy Aging, Technical University of Dresden (TUD), Dresden, Germany., Tsourdi E; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; Center for Healthy Aging, Technical University of Dresden (TUD), Dresden, Germany., Sockel K; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; Department of Medicine I and., Schneider M; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; Department of Hematology and Cell Therapy, University Hospital Leipzig (UHL), Leipzig, Germany., Kubasch AS; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; Department of Hematology and Cell Therapy, University Hospital Leipzig (UHL), Leipzig, Germany., Nolde M; Orthopedic Center Bogenhausen, Munich, Germany., Hausmann D; Orthopedic Center Bogenhausen, Munich, Germany., Paulus AC; Department of Orthopedic Surgery, LMU, Munich, Germany., Lützner J; Department of Orthopedic Surgery, TUD, Dresden, Germany., Roth A; Department of Orthopedic Surgery, UHL, Leipzig, Germany., Bassermann F; Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany.; German Cancer Research Center, Heidelberg, Germany.; TranslaTUM, Center for Translational Cancer Research, TUM, Munich, Germany; and., Spiekermann K; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany., Marr C; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hofbauer LC; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Center for Healthy Aging, Technical University of Dresden (TUD), Dresden, Germany., Platzbecker U; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Department of Hematology and Cell Therapy, University Hospital Leipzig (UHL), Leipzig, Germany., Metzeler KH; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany.; Department of Hematology and Cell Therapy, University Hospital Leipzig (UHL), Leipzig, Germany., Götze KS; Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany.; German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany.; German Cancer Research Center, Heidelberg, Germany. |
| المصدر: | Blood [Blood] 2021 Nov 04; Vol. 138 (18), pp. 1727-1732. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New York, Grune & Stratton [etc.] |
| مواضيع طبية MeSH: | Arthroplasty, Replacement, Hip* , Clonal Hematopoiesis* , Gene Frequency* , Mutation*, Autoimmune Diseases/*genetics, Adult ; Aged ; Aged, 80 and over ; Autoimmune Diseases/complications ; Cells, Cultured ; DNA Methyltransferase 3A/genetics ; DNA-Binding Proteins/genetics ; Dioxygenases/genetics ; Humans ; Male ; Middle Aged ; Young Adult |
| مستخلص: | Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and cardiovascular disease (CVD). Murine models demonstrate CH-mediated altered immune function and proinflammation. Low-grade inflammation has been implicated in the pathogenesis of osteoarthritis (OA), the main indication for total hip arthroplasty (THA). THA-derived hip bones serve as a major source of healthy hematopoietic cells in experimental hematology. We prospectively investigated frequency and clinical associations of CH in 200 patients without known hematologic disease who were undergoing THA. Prevalence of CH was 50%, including 77 patients with CH of indeterminate potential (CHIP, defined as somatic variant allele frequencies [VAFs] ≥2%), and 23 patients harboring CH with lower mutation burden (VAF, 1% to 2%). Most commonly mutated genes were DNMT3A (29.5%), TET2 (15.0%), and ASXL1 (3.5%). CHIP is significantly associated with lower hemoglobin, higher mean corpuscular volume, previous or present malignant disease, and CVD. Strikingly, we observed a previously unreported association of CHIP with autoimmune diseases (AIDs; multivariable adjusted odds ratio, 6.6; 95% confidence interval, 1.7-30; P = .0081). These findings underscore the association between CH and inflammatory diseases. Our results have considerable relevance for managing patients with OA and AIDs or mild anemia and question the use of hip bone-derived cells as healthy experimental controls. (© 2021 by The American Society of Hematology.) |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (DNMT3A protein, human) EC 1.13.11.- (Dioxygenases) EC 1.13.11.- (TET2 protein, human) EC 2.1.1.37 (DNA Methyltransferase 3A) |
| تواريخ الأحداث: | Date Created: 20210617 Date Completed: 20211209 Latest Revision: 20211214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1182/blood.2020010163 |
| PMID: | 34139005 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1528-0020 |
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| DOI: | 10.1182/blood.2020010163 |