دورية أكاديمية
Peripheral mechanisms involved in Tityus bahiensis venom-induced pain.
| العنوان: | Peripheral mechanisms involved in Tityus bahiensis venom-induced pain. |
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| المؤلفون: | Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Manchope MF; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Andrade KC; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Franciosi A; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Bagatim-Souza J; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Borghi SM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Paraná, Brazil., Cândido DM; Arthropod Laboratory, Butantan Institute, São Paulo, São Paulo, Brazil., Knysak I; Arthropod Laboratory, Butantan Institute, São Paulo, São Paulo, Brazil., Casagrande R; Department of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina, Paraná, Brazil., Kwasniewski FH; Department of Pathology, Londrina State University, Londrina, Paraná, Brazil. Electronic address: fhkwas@uol.com.br., Verri WA; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil; Department of Pathology, Londrina State University, Londrina, Paraná, Brazil. Electronic address: waverri@uel.br. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 Sep; Vol. 200, pp. 3-12. Date of Electronic Publication: 2021 Jun 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Pain*/chemically induced , Pain*/drug therapy , Venoms*, Animals ; Hyperalgesia/chemically induced ; Scorpions ; Tumor Necrosis Factor-alpha |
| مستخلص: | Scorpionism is a public health burden in Brazil. Tityus bahiensis is responsible for most accidents in the Southeastern region of Brazil. Here, the hyperalgesic mechanisms of Tityus bahiensis venom were investigated, focusing on the role of pro-inflammatory cytokines (tumor necrosis factor alpha [TNF-α] and interleukin 1 beta [IL-1β]) and activation of the transcription factor NFκB. Intraplantar (i.pl.) administration of Tityus bahiensis venom (0.2, 0.6, 1.2 and 2.4 μg/20 μL i.pl.) induced mechanical hyperalgesia and thermal hyperalgesia. The 2.4 μg dose of Tityus bahiensis venom induced overt pain-like behavior and increased myeloperoxidase (MPO) and N-acetyl-beta-D-glucosaminidase (NAG) activities, TNF-α and IL-1β levels in the paw tissue. Systemic pre-treatment with etanercept (soluble TNF-α receptor; 10 mg/kg), IL-1ra (IL-1 receptor antagonist; 30 mg/kg) and pyrrolidine dithiocarbamate (PDTC, nuclear factor kappa B [NFκB] inhibitor; 100 mg/kg) inhibited Tityus bahiensis venom-induced mechanical and thermal hyperalgesia, MPO and NAG activity and overt pain-like behavior. These data demonstrate the involvement of TNF-α and IL-1β signaling as well as NFκB activation in Tityus bahiensis venom-induced mechanical and thermal hyperalgesia, overt pain-like behavior, and MPO activity and NAG activity, indicating thus, that targeting these mechanisms might contribute to reducing the pain in this scorpionism. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cytokines; Hyperalgesia; NFκB; Pain; Tityus bahiensis |
| المشرفين على المادة: | 0 (Tumor Necrosis Factor-alpha) 0 (Venoms) |
| تواريخ الأحداث: | Date Created: 20210621 Date Completed: 20210907 Latest Revision: 20210907 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.toxicon.2021.06.013 |
| PMID: | 34153310 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2021.06.013 |