دورية أكاديمية
Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study.
| العنوان: | Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study. |
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| المؤلفون: | de Moura E Silva VEL; Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), 'Ministro Petrônio Portella' Campus, PI, 64049-550, Teresina, Brazil., Cholewa JM; Department of Exercise Physiology, University of Lynchburg, Lynchburg, VA, United States., Jäger R; Increnovo LLC, 2138 E Lafayette Pl, 53202, Milwaukee, WI, United States., Zanchi NE; Laboratory of Cellular and Molecular Biology of Skeletal Muscle (LABCEMME), Department of Physical Education, Federal University of Maranhão, São Luís, Brazil., de Freitas MC; Department of Nutrition, University of Western São Paulo (UNOESTE), Presidente Prudente, Brazil., de Moura RC; Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), 'Ministro Petrônio Portella' Campus, PI, 64049-550, Teresina, Brazil., Barros EML; Department of Biophysics and Physiology, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil., Antunes BM; Exercise and Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Caperuto EC; University São Judas Tadeu, São Paulo, SP, Brazil., Ribeiro SLG; Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), 'Ministro Petrônio Portella' Campus, PI, 64049-550, Teresina, Brazil., Lira FS; Exercise and Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Pereira Dos Santos MA; Department of Biophysics and Physiology, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil., Rossi FE; Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), 'Ministro Petrônio Portella' Campus, PI, 64049-550, Teresina, Brazil. fabriciorossi@ufpi.edu.br.; Associate Professor at Graduation Program in Science and Health, Federal University of Piaui (UFPI), Teresina-PI, Brazil. fabriciorossi@ufpi.edu.br. |
| المصدر: | Journal of the International Society of Sports Nutrition [J Int Soc Sports Nutr] 2021 Jun 21; Vol. 18 (1), pp. 50. Date of Electronic Publication: 2021 Jun 21. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101234168 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-2783 (Electronic) Linking ISSN: 15502783 NLM ISO Abbreviation: J Int Soc Sports Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [Philadelphia, PA] : Taylor & Francis Original Publication: [Woodland Park, Colo.] : International Society of Sports Nutrition, [2004]- |
| مواضيع طبية MeSH: | Capsaicin/*analogs & derivatives , Inflammation Mediators/*blood , Muscle Strength/*drug effects , Resistance Training/*methods, Adult ; Athletic Performance ; Body Composition/drug effects ; Body Water/drug effects ; Body Water/metabolism ; Capsaicin/administration & dosage ; Capsaicin/pharmacology ; Double-Blind Method ; Humans ; Interleukin-10/blood ; Interleukin-6/blood ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Receptors, Tumor Necrosis Factor/blood ; Tumor Necrosis Factor-alpha/blood ; Young Adult |
| مستخلص: | Background: Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflammatory response and performance in untrained men. Methods: Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design. Body composition and performance were measured at pre-training and after 6 weeks of resistance training. An acute resistance exercise session test was performed pre and post-intervention. Blood samples were collected at rest and post-resistance exercise to analyze Tumor necrosis factor- (TNF-), Soluble TNF- receptor (sTNF-r), Interleukin-6 (IL-6) and Interleukin-10 (IL-10). Results: Exercise and CAP supplementation increased fat-free mass in comparison to baseline by 1.5 kg (P < 0.001), however, the majority of the increase (1.0 kg) resulted from an increase in total body water. The CAP change scores for fat-free mass were significantly greater in comparison to the placebo (CAP ∆%= 2.1 ± 1.8 %, PLA ∆%= 0.7 ± 1.3 %, P = 0.043) and there was a significant difference between groups in the bench press exercise (P = 0.034) with greater upper body strength change score for CAP (∆%= 13.4 ± 9.1 %) compared to placebo (∆%= 5.8 ± 5.2 %), P = 0.041. CAP had no effect on lower body strength and no supplementation interactions were observed for all cytokines in response to acute resistance exercise (P > 0.05). Conclusion: Chronic Capsiate supplementation combined with resistance training during short period (6 weeks) increased fat-free mass and upper body strength but not inflammatory response and performance in young untrained men. |
| References: | J Biol Chem. 2012 Jun 1;287(23):19462-71. (PMID: 22493457) Int J Sports Physiol Perform. 2021 Jan 12;16(4):464-473. (PMID: 33383571) J Int Soc Sports Nutr. 2009 Feb 27;6:7. (PMID: 19250531) J Appl Physiol (1985). 2017 Mar 1;122(3):683-694. (PMID: 27979980) PLoS One. 2013;8(3):e58673. (PMID: 23536811) Front Pharmacol. 2017 Jan 10;7:538. (PMID: 28119613) Int J Sports Med. 2019 Dec;40(13):813-817. (PMID: 31614381) Curr Pharm Biotechnol. 2011 Jan 1;12(1):122-9. (PMID: 20932251) Nature. 2015 Dec 10;528(7581):276-9. (PMID: 26560032) Front Physiol. 2018 Oct 09;9:1376. (PMID: 30356748) J Strength Cond Res. 2018 Aug;32(8):2227-2232. (PMID: 28682933) Channels (Austin). 2013 May-Jun;7(3):221-4. (PMID: 23584166) PLoS One. 2013 Nov 08;8(11):e78184. (PMID: 24250792) Crit Rev Food Sci Nutr. 2018 Jun 13;58(9):1419-1427. (PMID: 28001433) Eur J Appl Physiol. 2010 Aug;109(6):1095-102. (PMID: 20369365) Nutrients. 2016 Oct 20;8(10):. (PMID: 27775591) J Appl Physiol (1985). 2005 Apr;98(4):1154-62. (PMID: 15772055) |
| فهرسة مساهمة: | Keywords: Hypertrophy; Performance; Pre-workout; Strength training |
| المشرفين على المادة: | 0 (Inflammation Mediators) 0 (Interleukin-6) 0 (Receptors, Tumor Necrosis Factor) 0 (Tumor Necrosis Factor-alpha) 130068-27-8 (Interleukin-10) PX8I7HG5I3 (capsiate) S07O44R1ZM (Capsaicin) |
| تواريخ الأحداث: | Date Created: 20210622 Date Completed: 20210705 Latest Revision: 20210705 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8218493 |
| DOI: | 10.1186/s12970-021-00446-0 |
| PMID: | 34154603 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1550-2783 |
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| DOI: | 10.1186/s12970-021-00446-0 |