دورية أكاديمية

Biomarkers of ketamine's antidepressant effect: a clinical review of genetics, functional connectivity, and neurophysiology.

التفاصيل البيبلوغرافية
العنوان: Biomarkers of ketamine's antidepressant effect: a clinical review of genetics, functional connectivity, and neurophysiology.
المؤلفون: Alario AA; Department of Psychiatry and Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USA., Niciu MJ; Department of Psychiatry and Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USA.
المصدر: Chronic stress (Thousand Oaks, Calif.) [Chronic Stress (Thousand Oaks)] 2021 May 31; Vol. 5, pp. 24705470211014210. Date of Electronic Publication: 2021 May 31 (Print Publication: 2021).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 101701229 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-5470 (Electronic) Linking ISSN: 24705470 NLM ISO Abbreviation: Chronic Stress (Thousand Oaks) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Thousand Oaks, Calif. : Sage Publications, [2017]-
مستخلص: Major depressive disorder (MDD) is one of the leading causes of morbidity and all-cause mortality (including suicide) worldwide, and, unfortunately, first-line monoaminergic antidepressants and evidence-based psychotherapies are not effective for all patients. Subanesthetic doses of the N-methyl-D-aspartate receptor antagonists and glutamate modulators ketamine and S-ketamine have rapid and robust antidepressant efficacy in such treatment-resistant depressed patients (TRD). Yet, as with all antidepressant treatments including electroconvulsive therapy (ECT), not all TRD patients adequately respond, and we are presently unable to a priori predict who will respond or not respond to ketamine. Therefore, antidepressant treatment response biomarkers to ketamine have been a major focus of research for over a decade. In this article, we review the evidence in support of treatment response biomarkers, with a particular focus on genetics, functional magnetic resonance imaging, and neurophysiological studies, i.e. electroencephalography and magnetoencephalography. The studies outlined here lay the groundwork for replication and dissemination.
Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2021.)
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معلومات مُعتمدة: R00 AA024142 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: electroencephalography; functional magnetic resonance imaging; genetics; glutamate; ketamine; magnetoencephalography; major depressive disorder; treatment resistant depression
تواريخ الأحداث: Date Created: 20210623 Latest Revision: 20221026
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8186113
DOI: 10.1177/24705470211014210
PMID: 34159281
قاعدة البيانات: MEDLINE
الوصف
تدمد:2470-5470
DOI:10.1177/24705470211014210