دورية أكاديمية
أعرض في EDS

Diagnostic Value of 14 C Urea Breath Test for Helicobacter pylori Detection Compared by Histopathology in Indonesian Dyspeptic Patients.

التفاصيل البيبلوغرافية
العنوان: Diagnostic Value of 14 C Urea Breath Test for Helicobacter pylori Detection Compared by Histopathology in Indonesian Dyspeptic Patients.
المؤلفون: Miftahussurur M; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia., Windia A; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Syam AF; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia., Nusi IA; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Alfaray RI; Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia.; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, 879-5593, Japan., Fauzia KA; Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia.; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, 879-5593, Japan., Kahar H; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Purbayu H; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Sugihartono T; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Setiawan PB; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Maimunah U; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Kholili U; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Thamrin H; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Vidyani A; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia., Doohan D; Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia., Waskito LA; Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia., Rezkitha YAA; Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia.; Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, East Java, 60113, Indonesia., Siregar GA; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia., Yamaoka Y; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia.; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, 879-5593, Japan.
المصدر: Clinical and experimental gastroenterology [Clin Exp Gastroenterol] 2021 Jun 14; Vol. 14, pp. 291-296. Date of Electronic Publication: 2021 Jun 14 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101532800 Publication Model: eCollection Cited Medium: Print ISSN: 1178-7023 (Print) Linking ISSN: 11787023 NLM ISO Abbreviation: Clin Exp Gastroenterol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Auckland, N.Z.] : Dove Medical Press, c2008-
مستخلص: Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as 14 C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet.
Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and 14 C-UBT test. We used Heliprobe ® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System.
Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861-1.000). By applying the optimum cut-off value, Heliprobe ® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy.
Conclusion: The 14 C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population.
Competing Interests: The authors report no conflicts of interest in this work.
(© 2021 Miftahussurur et al.)
References: World J Gastroenterol. 2014 Jun 7;20(21):6412-9. (PMID: 24914362)
World J Gastroenterol. 2005 Mar 7;11(9):1361-4. (PMID: 15761976)
Acta Med Indones. 2017 Jul;49(3):279-287. (PMID: 29093241)
Ann Glob Health. 2019 Jul 24;85(1):. (PMID: 31348624)
Clin Microbiol Rev. 2006 Jul;19(3):449-90. (PMID: 16847081)
PLoS One. 2015 Nov 23;10(11):e0140186. (PMID: 26599790)
Helicobacter. 2011 Aug;16(4):327-37. (PMID: 21762274)
Dig Endosc. 2014 Apr;26 Suppl 2:2-9. (PMID: 24750141)
Ont Health Technol Assess Ser. 2013 Oct 01;13(20):1-28. (PMID: 24228083)
J Pathog. 2018 May 22;2018:9064952. (PMID: 29951318)
Saudi J Gastroenterol. 2009 Jul-Sep;15(3):201-7. (PMID: 19636185)
PLoS One. 2018 Nov 14;13(11):e0205644. (PMID: 30427843)
Korean J Intern Med. 2016 Sep;31(5):835-44. (PMID: 27604795)
Cochrane Database Syst Rev. 2018 Mar 15;3:CD012080. (PMID: 29543326)
Biomed Res Int. 2015;2015:152823. (PMID: 26824034)
Intern Med. 2008;47(12):1077-83. (PMID: 18552463)
Gastroenterol Res Pract. 2011;2011:930941. (PMID: 21760778)
Gastroenterol Hepatol Bed Bench. 2015 Spring;8(Suppl 1):S6-S14. (PMID: 26171139)
Helicobacter. 2010 Sep;15 Suppl 1:14-20. (PMID: 21054648)
Aliment Pharmacol Ther. 2004 Nov 15;20(10):1001-17. (PMID: 15569102)
Can J Gastroenterol. 2003 Jun;17 Suppl B:30B-32B. (PMID: 12845348)
J Adv Res. 2018 Jan 31;13:51-57. (PMID: 30094082)
World J Gastroenterol. 2007 Feb 14;13(6):925-9. (PMID: 17352025)
Am J Surg Pathol. 1996 Oct;20(10):1161-81. (PMID: 8827022)
Medicina (Kaunas). 2007;43(1):32-5. (PMID: 17297281)
Biomed Res Int. 2016;2016:4819423. (PMID: 26904678)
Ann Transl Med. 2015 Jan;3(1):10. (PMID: 25705642)
معلومات مُعتمدة: R01 DK062813 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Helicobacter pylori; UBT; diagnostic; infectious disease
تواريخ الأحداث: Date Created: 20210624 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8213946
DOI: 10.2147/CEG.S306626
PMID: 34163206
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-7023
DOI:10.2147/CEG.S306626