دورية أكاديمية
أعرض في EDS

Native Spleen Preservation During Visceral Transplantation Inhibits Graft-Versus-Host-Disease Development: Clinical and Experimental Study.

التفاصيل البيبلوغرافية
العنوان: Native Spleen Preservation During Visceral Transplantation Inhibits Graft-Versus-Host-Disease Development: Clinical and Experimental Study.
المؤلفون: Stringa P; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain.; Institute for Immunological and Pathophysiological Studies (IIFP), School of Exact Sciences, National University of La Plata, National Council of Scientific and Technical Research (cONIcET), La Plata, Argentina., Papa-Gobbi R; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Vela M; Translational Research Group in Childhood Cancer, Hematopoietic Transplant and cell Therapy, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain., Gentilini MV; Intestinal Failure, Rehabilitation and Transplant Unit, University Hospital Favaloro Foundation; Institute of Translational Medicine, Transplantation and Bioengineering (ImeTTyB), University Favaloro-CONICET, Buenos Aires, Argentina., Machuca M; Special Pathology Laboratory, Faculty of Veterinary Sciences, National University of La Plata, La Plata, Buenos Aires, Argentina., Klin P; Telemetry Unit. Favaloro Foundation. University Hospital, Buenos Aires, Argentina., Arreola NM; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Serradilla J; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Bueno A; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Andrés AM; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Ramos E; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Alcolea A; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Pérez-Martínez A; Translational Research Group in Childhood Cancer, Hematopoietic Transplant and cell Therapy, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain., Prieto G; Healthcare System Emeritus, La Paz University Hospital, Madrid, Spain; and., López-Santamaría M; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain., Gondolesi G; Special Pathology Laboratory, Faculty of Veterinary Sciences, National University of La Plata, La Plata, Buenos Aires, Argentina., Rumbo M; Institute for Immunological and Pathophysiological Studies (IIFP), School of Exact Sciences, National University of La Plata, National Council of Scientific and Technical Research (cONIcET), La Plata, Argentina., Hernández F; Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain.; Executive Operational Committee, ERN TRANSPLANTCHILD, Madrid, Spain.
المصدر: Annals of surgery [Ann Surg] 2023 Jan 01; Vol. 277 (1), pp. e235-e244. Date of Electronic Publication: 2021 Jun 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0372354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1140 (Electronic) Linking ISSN: 00034932 NLM ISO Abbreviation: Ann Surg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Bone Marrow Transplantation* , Graft vs Host Disease*, Rats ; Animals ; Mice ; Spleen ; Transplantation, Homologous ; T-Lymphocytes ; Mice, Inbred C57BL
مستخلص: Objective: We aimed to assess whether native spleen preservation during visceral transplantation (VT) affects graft-versus-host-disease (GVHD) incidence.
Summary Background Data: GVHD is one of the most severe and frequently lethal hematological complications after VT procedures. Because there is no specific treatment for GVHD, it is imperative to develop a strategy to reduce donor lymphocyte engraftment and proliferation.
Methods: Our study included both clinical and experimental data. A total of 108 patients were divided into 3 groups: a native spleen preservation group, a native spleen removal with no donor spleen group, and a donor spleen included (allogeneic spleen) group. We also used an allogeneic VT rat model, in which recipients were divided into 2 groups: a native spleen preservation (+SP) group and a native spleen removal (-S) group. Skin rash appearance, histopathological changes, chimerism, and spleen effects on circulating allogeneic T-cells were assessed.
Results: The patients with native spleen preservation showed a lower rate of GVHD ( P <.001) and better survival ( P <.05) than those in the other groups. Skin and histological signs of GVHD were lower in the rats in the +SP group ( P <.05). The donor T-cell frequency in the bloodstream and skin was also significantly reduced when the native spleen was preserved ( P <.01 and P <.0001, respectively).
Conclusions: The clinical and experimental data indicate that recipient spleen preservation protects against GVHD after VT, and donor cell clearance from the bloodstream by spleen macrophages could be the underlying mechanism. Therefore, spleen preservation should be considered in VT procedures, whenever possible.
Competing Interests: The authors report no conflicts of interest.
(Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20210625 Date Completed: 20230228 Latest Revision: 20240712
رمز التحديث: 20240712
DOI: 10.1097/SLA.0000000000004979
PMID: 34171860
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-1140
DOI:10.1097/SLA.0000000000004979