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Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya.

التفاصيل البيبلوغرافية
العنوان: Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya.
المؤلفون: Adetifa IMO; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. IAdetifa@kemri-wellcome.org.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. IAdetifa@kemri-wellcome.org., Uyoga S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. SUyoga@kemri-wellcome.org., Gitonga JN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mugo D; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Otiende M; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Nyagwange J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Karanja HK; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Tuju J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Wanjiku P; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Aman R; Ministry of Health, Government of Kenya, Nairobi, Kenya., Mwangangi M; Ministry of Health, Government of Kenya, Nairobi, Kenya., Amoth P; Ministry of Health, Government of Kenya, Nairobi, Kenya., Kasera K; Ministry of Health, Government of Kenya, Nairobi, Kenya., Ng'ang'a W; Presidential Policy & Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya., Rombo C; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Yegon C; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Kithi K; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Odhiambo E; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Rotich T; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Orgut I; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Kihara S; Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya., Bottomley C; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom., Kagucia EW; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Gallagher KE; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom., Etyang A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Voller S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom., Lambe T; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom., Wright D; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom., Barasa E; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Tsofa B; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Bejon P; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom., Ochola-Oyier LI; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Agweyu A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Scott JAG; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom., Warimwe GM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.
المصدر: Nature communications [Nat Commun] 2021 Jun 25; Vol. 12 (1), pp. 3966. Date of Electronic Publication: 2021 Jun 25.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Antibodies, Viral/*immunology , COVID-19/*diagnosis , SARS-CoV-2/*immunology , Spike Glycoprotein, Coronavirus/*immunology, Adolescent ; Adult ; Antibodies, Viral/blood ; Bayes Theorem ; COVID-19/epidemiology ; COVID-19/virology ; Enzyme-Linked Immunosorbent Assay ; Epidemics ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Kenya/epidemiology ; Male ; Middle Aged ; Prevalence ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Seroepidemiologic Studies ; Spike Glycoprotein, Coronavirus/metabolism ; Young Adult
مستخلص: Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.
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معلومات مُعتمدة: INV-017547 United States GATES Bill & Melinda Gates Foundation; 214320 United Kingdom WT_ Wellcome Trust; 218647 United Kingdom WT_ Wellcome Trust; MR/R006083/1 United Kingdom MRC_ Medical Research Council; MR/S005293/1 United Kingdom MRC_ Medical Research Council; 203077 United Kingdom WT_ Wellcome Trust; 107568 United Kingdom WT_ Wellcome Trust; 222574 United Kingdom WT_ Wellcome Trust; EP-C-15-003 United States EPA EPA; United Kingdom WT_ Wellcome Trust; MR/R010161/1 United Kingdom MRC_ Medical Research Council; 220991 United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Antibodies, Viral)
0 (Immunoglobulin G)
0 (Spike Glycoprotein, Coronavirus)
0 (spike protein, SARS-CoV-2)
تواريخ الأحداث: Date Created: 20210626 Date Completed: 20210719 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC8233334
DOI: 10.1038/s41467-021-24062-3
PMID: 34172732
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-021-24062-3