دورية أكاديمية
Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.
| العنوان: | Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. |
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| المؤلفون: | da Silva DT; Post Graduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Smaniotto FA; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Costa IF; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Baranzelli J; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Muller A; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Somacal S; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Monteiro CS; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Vizzotto M; Empresa Brasileira de Pesquisa Agropecuária, Embrapa Clima Temperado, 96010-971 Pelotas, RS, Brazil., Rodrigues E; Institute of Food Science and Technology, Federal University of Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil., Barcia MT; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Emanuelli T; Integrated Center for Laboratory Analysis Development, Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address: tatiana.emanuelli@ufsm.br. |
| المصدر: | Food chemistry [Food Chem] 2021 Dec 01; Vol. 364, pp. 130370. Date of Electronic Publication: 2021 Jun 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Barking : Elsevier Applied Science Publishers Original Publication: Barking, Eng., Applied Science Publishers. |
| مواضيع طبية MeSH: | Blueberry Plants*, Animals ; Anthocyanins ; Biological Availability ; Plant Extracts ; Rats ; Rats, Wistar ; Solvents ; Tandem Mass Spectrometry |
| مستخلص: | This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Absorption; Anthocyanins; Green solvent; Intestinal stability; Metabolites; Pharmacokinetic |
| المشرفين على المادة: | 0 (Anthocyanins) 0 (Plant Extracts) 0 (Solvents) |
| تواريخ الأحداث: | Date Created: 20210628 Date Completed: 20210924 Latest Revision: 20210924 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.foodchem.2021.130370 |
| PMID: | 34182361 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7072 |
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| DOI: | 10.1016/j.foodchem.2021.130370 |