دورية أكاديمية
أعرض في EDS

Non-permissive SARS-CoV-2 infection in human neurospheres.

التفاصيل البيبلوغرافية
العنوان: Non-permissive SARS-CoV-2 infection in human neurospheres.
المؤلفون: Pedrosa CDSG; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Goto-Silva L; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Temerozo JR; National Institute for Science and Technology on Neuroimmunomodulation (INCT/NIM), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; Laboratory on Thymus Research, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil., Souza LRQ; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Vitória G; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Ornelas IM; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Karmirian K; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Mendes MA; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Gomes IC; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Sacramento CQ; Immunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil., Fintelman-Rodrigues N; Immunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil., Cardoso Soares V; Immunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; Program of Immunology and Inflammation, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Silva Gomes Dias SD; Immunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil., Salerno JA; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Puig-Pijuan T; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Oliveira JT; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Aragão LGHS; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Torquato TCQ; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Veríssimo C; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Biagi D; Pluricell Biotech, São Paulo, SP, Brazil., Cruvinel EM; Pluricell Biotech, São Paulo, SP, Brazil., Dariolli R; Pluricell Biotech, São Paulo, SP, Brazil; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Furtado DR; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Borges HL; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Bozza PT; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil., Rehen S; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address: srehen@lance-ufrj.org., Moreno L Souza T; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; Program of Immunology and Inflammation, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address: tmoreno@cdts.fiocruz.br., Guimarães MZP; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address: marilia@lance-ufrj.org.
المصدر: Stem cell research [Stem Cell Res] 2021 Jul; Vol. 54, pp. 102436. Date of Electronic Publication: 2021 Jun 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kidlington, Oxford : Elsevier
مواضيع طبية MeSH: COVID-19* , SARS-CoV-2*, Brain ; Humans ; Inflammation
مستخلص: Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.
(Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: Brain; Neurospheres; New coronavirus; SARS-CoV-2; iPS
تواريخ الأحداث: Date Created: 20210629 Date Completed: 20210715 Latest Revision: 20230329
رمز التحديث: 20230329
مُعرف محوري في PubMed: PMC8236004
DOI: 10.1016/j.scr.2021.102436
PMID: 34186311
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-7753
DOI:10.1016/j.scr.2021.102436