دورية أكاديمية
Mean macular intercapillary area in eyes with diabetic macular oedema after anti-vascular endothelial growth factor therapy and its association with treatment response.
| العنوان: | Mean macular intercapillary area in eyes with diabetic macular oedema after anti-vascular endothelial growth factor therapy and its association with treatment response. |
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| المؤلفون: | Sorour OA; Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt.; New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Elsheikh M; Department of Geomatics Engineering, University of Calgary, Calgary, Canada.; Department of Electronics and Electrical Communications Engineering, Tanta University, Tanta, Egypt., Chen S; Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Elnahry AG; Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt., Baumal CR; New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Pramil V; New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Abdelhalim TI; Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt., Nassar E; Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt., Moult EM; Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Witkin AJ; New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Duker JS; New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Waheed NK; New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA. |
| المصدر: | Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2021 Sep; Vol. 49 (7), pp. 714-723. Date of Electronic Publication: 2021 Aug 01. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Pub. Asia Country of Publication: Australia NLM ID: 100896531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1442-9071 (Electronic) Linking ISSN: 14426404 NLM ISO Abbreviation: Clin Exp Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Carlton, Vic. : Wiley-Blackwell Pub. Asia Original Publication: Carlton, Vic. : Blackwell Science Asia, c2000- |
| مواضيع طبية MeSH: | Diabetes Mellitus* , Diabetic Retinopathy*/diagnosis , Diabetic Retinopathy*/drug therapy , Macular Edema*/diagnosis , Macular Edema*/drug therapy , Macular Edema*/etiology, Angiogenesis Inhibitors/therapeutic use ; Humans ; Intravitreal Injections ; Ranibizumab/therapeutic use ; Retrospective Studies ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A ; Visual Acuity |
| مستخلص: | Background: To evaluate the changes in the mean macular intercapillary area (ICA) from sequential enface optical coherence tomography angiography (OCTA) images following intravitreal anti-vascular endothelial growth factor (VEGF) therapy in initially treatment-naïve eyes with diabetic macular oedema (DME). Methods: In this multicentre retrospective study, 6 × 6 and 3 × 3 mm customised, total retinal projection enface OCTA images were collected and processed for quantitative assessment of ICA by a customised MATLAB software. Measurements were done in concentric regions centred on the fovea-with the exclusion of foveal avascular zone (FAZ)-in 0.5 mm diameter increments as well as within the intervening rings. Results: In this study, 6 × 6 mm OCTA images from 46 eyes of 29 patients, and 3 × 3 mm OCTA images from 23 eyes of 15 patients were included. There was no significant change in mean ICA after treatment in either scan size or in any measurement regions (all p > 0.05). Multivariate analysis revealed that baseline BCVA was significantly correlated with the visual outcome (p = 0.039). Additionally, after correction for age, baseline central retinal thickness (CRT), baseline BCVA, and retinopathy severity, mean ICA in the 1.5 mm circle was found to be a significant predictor of post treatment CRT, (p = 0.006). Conclusions: Absence of significant change in mean ICA after a minimum of three intravitreal anti-VEGF injections, may indicate that, in the short term, anti-VEGF injections neither impair nor improve macular perfusion in DME. Baseline BCVA was found to be a robust predictor of functional outcome, while inner mean ICA was a significant predictor for macular thickness outcomes. (© 2021 Royal Australian and New Zealand College of Ophthalmologists.) |
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| فهرسة مساهمة: | Keywords: OCT; anti-VEGF; diabetic macular oedema; diabetic retinopathy; intravitreal |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (Vascular Endothelial Growth Factor A) ZL1R02VT79 (Ranibizumab) |
| تواريخ الأحداث: | Date Created: 20210630 Date Completed: 20211025 Latest Revision: 20211025 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/ceo.13966 |
| PMID: | 34189816 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1442-9071 |
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| DOI: | 10.1111/ceo.13966 |