دورية أكاديمية
أعرض في EDS

Blinding in Clinical Trials: Seeing the Big Picture.

التفاصيل البيبلوغرافية
العنوان: Blinding in Clinical Trials: Seeing the Big Picture.
المؤلفون: Monaghan TF; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Agudelo CW; Division of Cardiovascular Medicine, Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA., Rahman SN; Department of Urology, Yale University School of Medicine, New Haven, CT 06520, USA., Wein AJ; Division of Urology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Lazar JM; Division of Cardiovascular Medicine, Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA., Everaert K; Department of Human Structure and Repair, Ghent University, 9000 Ghent, Belgium., Dmochowski RR; Department of Urological Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
المصدر: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2021 Jun 24; Vol. 57 (7). Date of Electronic Publication: 2021 Jun 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Basel, Switzerland : MDPI
Original Publication: Kaunas : Lietuvos gydytojų sąjunga
مواضيع طبية MeSH: Single-Blind Method*, Bias ; Double-Blind Method ; Humans
مستخلص: Blinding mitigates several sources of bias which, if left unchecked, can quantitively affect study outcomes. Blinding remains under-utilized, particularly in non-pharmaceutical clinical trials, but is often highly feasible through simple measures. Although blinding is generally viewed as an effective method by which to eliminate bias, blinding does also pose some inherent limitations, and it behooves clinicians and researchers to be aware of such caveats. This article will review general principles for blinding in clinical trials, including examples of useful blinding techniques for both pharmaceutical and non-pharmaceutical trials, while also highlighting the limitations and potential consequences of blinding. Appropriate reporting on blinding in trial protocols and manuscripts, as well as future directions for blinding research, will also be discussed.
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فهرسة مساهمة: Keywords: bias; blinding; clinical trials; double; single; triple
تواريخ الأحداث: Date Created: 20210702 Date Completed: 20210705 Latest Revision: 20210727
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8308085
DOI: 10.3390/medicina57070647
PMID: 34202486
قاعدة البيانات: MEDLINE
الوصف
تدمد:1648-9144
DOI:10.3390/medicina57070647