دورية أكاديمية
أعرض في EDS

Impact TMPRSS2-ERG Molecular Subtype on Prostate Cancer Recurrence.

التفاصيل البيبلوغرافية
العنوان: Impact TMPRSS2-ERG Molecular Subtype on Prostate Cancer Recurrence.
المؤلفون: Kobelyatskaya AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia., Pudova EA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Snezhkina AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Fedorova MS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Pavlov VS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Guvatova ZG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Savvateeva MV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Melnikova NV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Dmitriev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Trofimov DY; Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia., Sukhikh GT; Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia., Nyushko KM; National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia., Alekseev BY; National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia., Razin SV; Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia., Krasnov GS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Kudryavtseva AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
المصدر: Life (Basel, Switzerland) [Life (Basel)] 2021 Jun 21; Vol. 11 (6). Date of Electronic Publication: 2021 Jun 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Currently, seven molecular subtypes of prostate cancer (PCa) are known, the most common of which being the subtype characterized by the presence of the TMPRSS2-ERG fusion transcript. While there is a considerable amount of work devoted to the influence of this transcript on the prognosis of the disease, data on its role in the progression and prognosis of PCa remain controversial. The present study is devoted to the analysis of the association between the TMPRSS2-ERG transcript and the biochemical recurrence of PCa. The study included two cohorts: the RNA-Seq sample of Russian patients with PCa ( n = 72) and the TCGA-PRAD data ( n = 203). The results of the analysis of the association between the TMPRSS2-ERG transcript and biochemical recurrence were contradictory. The differential expression analysis (biochemical recurrence cases versus biochemical recurrence-free) and the gene set enrichment analysis revealed a list of genes involved in major cellular pathways. The GNL3 , QSOX2 , SSPO , and SYS1 genes were selected as predictors of the potential prognostic model (AUC = 1.000 for a cohort of Russian patients with PCa and AUC = 0.779 for a TCGA-PRAD cohort).
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معلومات مُعتمدة: 18-75-10127 Russian Science Foundation
فهرسة مساهمة: Keywords: RNA–Seq; TMPRSS2–ERG molecular subtype; gene expression; prostate cancer; tumor recurrence
تواريخ الأحداث: Date Created: 20210702 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8234735
DOI: 10.3390/life11060588
PMID: 34205581
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-1729
DOI:10.3390/life11060588