دورية أكاديمية

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform.

التفاصيل البيبلوغرافية
العنوان: Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform.
المؤلفون: Selvarajan RS; Institute of Microengineering and Nanoelectronics (IMEN), National University of Malaysia (UKM), Bangi 43600, Malaysia., Gopinath SCB; Institute of Nano Electronic Engineering (INEE), University Malaysia Perlis (UniMAP), Kangar 01000, Malaysia., Zin NM; Center for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, National University of Malaysia (UKM), Kuala Lumpur 50300, Malaysia., Hamzah AA; Institute of Microengineering and Nanoelectronics (IMEN), National University of Malaysia (UKM), Bangi 43600, Malaysia.
المصدر: Sensors (Basel, Switzerland) [Sensors (Basel)] 2021 Jun 01; Vol. 21 (11). Date of Electronic Publication: 2021 Jun 01.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2000-
مواضيع طبية MeSH: Biosensing Techniques* , COVID-19*, Biomarkers ; COVID-19 Testing ; Humans ; Pandemics ; SARS-CoV-2
مستخلص: The race towards the development of user-friendly, portable, fast-detection, and low-cost devices for healthcare systems has become the focus of effective screening efforts since the pandemic attack in December 2019, which is known as the coronavirus disease 2019 (COVID-19) pandemic. Currently existing techniques such as RT-PCR, antigen-antibody-based detection, and CT scans are prompt solutions for diagnosing infected patients. However, the limitations of currently available indicators have enticed researchers to search for adjunct or additional solutions for COVID-19 diagnosis. Meanwhile, identifying biomarkers or indicators is necessary for understanding the severity of the disease and aids in developing efficient drugs and vaccines. Therefore, clinical studies on infected patients revealed that infection-mediated clinical biomarkers, especially pro-inflammatory cytokines and acute phase proteins, are highly associated with COVID-19. These biomarkers are undermined or overlooked in the context of diagnosis and prognosis evaluation of infected patients. Hence, this review discusses the potential implementation of these biomarkers for COVID-19 electrical biosensing platforms. The secretion range for each biomarker is reviewed based on clinical studies. Currently available electrical biosensors comprising electrochemical and electronic biosensors associated with these biomarkers are discussed, and insights into the use of infection-mediated clinical biomarkers as prognostic and adjunct diagnostic indicators in developing an electrical-based COVID-19 biosensor are provided.
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معلومات مُعتمدة: AKU 254: HICoE (Fasa II) 'MEMS for Biomedical Devices 617 (artificial kidney)' Ministry of Higher Education, Malaysia
فهرسة مساهمة: Keywords: acute phase proteins; adjunct diagnostic biomarkers; cytokine storm; electrochemical sensors; electronic biosensors; pro-inflammatory cytokines; prognostic indicators
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20210702 Date Completed: 20210706 Latest Revision: 20231111
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8198817
DOI: 10.3390/s21113829
PMID: 34205852
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8220
DOI:10.3390/s21113829